QSB: Quantitative Simulation of Cell Migration in Porous Biomaterials

艾布拉姆斯0331191这个项目的目标是对人造多孔材料中迁移细胞的行为有一个定量的了解。具体地说，这需要了解(I)多孔微结构(平均孔径、内表面积、孔-孔相关长度)、(Ii)刺激物的分子传输(例如生长因子和其他细胞间信号分子)通过扩散(扩散率)、(Iii)细胞传输(最大速度、持久性、分散性)和(Iv)细胞对刺激物的响应(趋化和趋化)对观察到的细胞群体通过多孔介质的迁移速度的影响。这将通过开发一个离散的、在空间不均匀的3-D区域中的细胞运动的概率模型来实现，该模型包含了细胞对刺激分子依赖于时间的浓度场的响应和影响。该模型将被应用于三维多孔基质中血管生成的模拟，其中具体目标是了解吻合(即，融合两个芽形成环)的可能性对微体系结构参数和描述细胞信号产生和接收的参数的敏感性。该项目的结果和结论将作为课程模块纳入高级运输和数值方法课程。

Abrams 0331191The goal of this project is to gain a quantitative understanding of the behavior of migrating cells in synthetic porous materials. Specifically, this requires understanding the simultaneous effects of (i) the porous microarchitecture (mean pore size, internal surface area, pore-pore correlation length), (ii) molecular transport of stimulants, such as growth factors and other cell-to-cell signaling molecules, via diffusion (diffusivities), (iii) cell transport (maximum speed, persistence, dispersion), and (iv) cell response to stimulants (chemotaxis and chemokinesis), on the observed migration speed of a cell population through the porous medium. This will be achieved through the development of a discrete, probabilistic model of cell motion in spatially inhomogeneous 3-D domains, incorporating cell response to and influence on time-dependent concentration fields of stimulant molecules. The model will be applied to simulation of angiogenesis in three-dimensional porous matrices, where specific goals are understanding the sensitivity of the likelihood of anastomosis (i.e., fusing of two sprouts to form a loop) on microarchitectural parameters and parameters describing cell signal production and reception. Results and conclusions from the project will be incorporated as course modules in advanced transport and numerical methods courses.