QSB: Quantitative Simulation of Cell Migration in Porous Biomaterials

QSB：多孔生物材料中细胞迁移的定量模拟

• 批准号: 0331191
• 负责人: Cameron Abrams
• 金额: $ 9.61万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-11-01 至 2006-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0331191&HistoricalAwards=false
• 关键词: QSB; Quantitative; Simulation; Cell; Migration

Abrams 0331191The goal of this project is to gain a quantitative understanding of the behavior of migrating cells in synthetic porous materials. Specifically, this requires understanding the simultaneous effects of (i) the porous microarchitecture (mean pore size, internal surface area, pore-pore correlation length), (ii) molecular transport of stimulants, such as growth factors and other cell-to-cell signaling molecules, via diffusion (diffusivities), (iii) cell transport (maximum speed, persistence, dispersion), and (iv) cell response to stimulants (chemotaxis and chemokinesis), on the observed migration speed of a cell population through the porous medium. This will be achieved through the development of a discrete, probabilistic model of cell motion in spatially inhomogeneous 3-D domains, incorporating cell response to and influence on time-dependent concentration fields of stimulant molecules. The model will be applied to simulation of angiogenesis in three-dimensional porous matrices, where specific goals are understanding the sensitivity of the likelihood of anastomosis (i.e., fusing of two sprouts to form a loop) on microarchitectural parameters and parameters describing cell signal production and reception. Results and conclusions from the project will be incorporated as course modules in advanced transport and numerical methods courses.

Abrams 0331191该项目的目标是获得对合成多孔材料中迁移细胞行为的定量理解。具体而言，这需要理解（i）多孔微结构（平均孔径、内表面积、孔-孔相关长度），（ii）刺激物（如生长因子和其它细胞-细胞信号分子）通过扩散的分子转运（扩散系数），（iii）细胞转运（最大速度，持久性，分散性），和（iv）细胞对刺激物的反应（趋化性和趋化运动），对观察到的细胞群通过多孔介质的迁移速度的影响。这将是通过开发一个离散的，概率模型的细胞运动在空间上不均匀的3-D域，将细胞响应和影响时间依赖性浓度场的兴奋剂分子。该模型将应用于三维多孔基质中血管生成的模拟，其中具体目标是理解吻合可能性的敏感性（即，两个芽融合形成环）对微结构参数和描述细胞信号产生和接收的参数的影响。该项目的结果和结论将作为课程模块纳入高级运输和数值方法课程。