SGER: Fluid Dynamics of the Aorta During Left Ventricular Assistance

建议没有。主要研究者：KAREN D. MAY-NEWMANINSTITUTION: SAN DIEGO STATEUNIVERSITY左心室辅助期间主动脉的流体动力学这项研究的目标是通过提供使用左心室辅助装置（lvad）时通过原生心脏和主动脉的三维血流的详细信息，来改进左心室辅助装置（lvad）的设计及其与人体的整合。本研究项目的智力优势在于对通过心脏的血流与非搏动性lvad的相互作用有了基本的了解，建立了手术配置和主动脉吻合角度对血流异常的影响。提出的方法代表了lvad研究的新范式，通过应用基于流体力学的系统分析来研究这些装置与人体的相互作用。这些研究的发现将进一步引发关于将连续血流lvad作为永久性设备进行改进的最佳策略的问题。本研究项目的广泛影响是提高患者LVAD的性能和疗效，确定LVAD植入的最佳手术方法，建议恢复期间LVAD控制策略以优化结果，增加医疗保健提供者护理LVAD患者所需的信息，降低治疗充血性心力衰竭患者的成本。这项研究的结果将是最有用的外科医生，修改植入技术；工程师，改进LVAD的设计和控制策略；以及治疗充血性心力衰竭患者的医生。

PROPOSAL NO.: CTS-0333141PRINCIPAL INVESTIGATORS: KAREN D. MAY-NEWMANINSTITUTION: SAN DIEGO STATEUNIVERSITY FLUID DYNAMICS OF THE AORTA DURING LEFT VENTRICULAR ASSISTANCEThe goal of the proposed research is to improve the design of Left Ventricular Assist Devices (LVADs) and their integration into the human body by providing detailed information on the 3-D blood flow through the native heart and aorta when using these devices. The intellectual merits of this research program are to gain a fundamental understanding of the interaction of flow through the heart and nonpulsatile LVADs, establish the effect of surgical configuration and aortic anastomosis angle on flow abnormalities. The proposed approach represents a new paradigm regarding the study of LVADs, through application of a systematic analysis based on fluid mechanics to investigate the interaction of these devices with the human body. The findings of these studies will lead to further questions about the optimal strategies to improve continuous flow LVADs as permanent devices. The broader impacts of this research program are to improve the performance and efficacy of LVADs for patients, identify optimal surgical methods for LVAD implantation, suggest strategies for LVAD control during recovery that optimize outcome, add to the information health care providers need in caring for LVAD patients and decrease the cost of treating congestive heart failure patients. The results of this research will be most useful to surgeons, to modify implantation techniques; to engineers, for improvements in LVAD design and control strategies; and to physicians treating patients suffering from congestive heart failure.