US-UK Dissertation Enhancement: Evolution of Unusual Steroids in Lamprey Species

美英论文增强：七鳃鳗物种中不寻常类固醇的进化

• 批准号: 0336929
• 负责人: Weiming Li
• 金额: $ 1.16万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-15 至 2006-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0336929&HistoricalAwards=false
• 关键词: US; UK; Dissertation; Enhancement; Evolution

0336929LiThis U.S.-U.K. dissertation enhancement project involves Weiming Li of Michigan State University, doctoral student Mara Beth Bryan, and Andrew Scott of the U.K. Centre for Environment, Fisheries and Aquaculture Science. The award supports a two-month visit by the doctoral student to investigate the presence and possible functionality of unusual 15a-hydroxylated steroids in European river lamprey (Lampetra fluviatillis). This line of research enhances the dissertation effort currently focused on the structure and functionality of 15a-hyroxylated steroids in the sea lamprey (Petromyzon marinus). The goal is to determine if the 15a-hyroxylated steroids (gonadal steroids) are ancestral and universal in lampreys by investigating their role in the European river lamprey, the most derived lamprey genus. The objectives are to study the steroids in the river lamprey's gonadal tissues in vitro, steroid circulation and production in vivo, changes in steroid levels in response to GnRH administration. Research on steroids in lampreys has implications in evolution and biodiversity of endocrine functions, as lampreys are the earliest evolving extant vertebrate studied for the hypothalamus-pituitary-gonadal axis. However, most research has focused on hormones of the hypothalamus and pituitary, and has been conducted on a single species, the sea lamprey. This dissertation project extends these studies to gonadal steroids in several different species. The project takes advantage of access to unique facilities in the United Kingdom which house river lampreys. The results will further understanding of conservation and control efforts for various lamprey species, which in different parts of the world are endangered, threatened, or considered as an invasive species.

0336929 Li美国-英国论文改进项目涉及密歇根州立大学的李伟明、博士生玛拉·贝丝·布莱恩和英国的安德鲁·斯科特。环境、渔业和水产科学中心。 该奖项支持博士生进行为期两个月的访问，以调查欧洲河七鳃鳗（Lampetra fluviatillis）中不寻常的15 a-羟基化类固醇的存在和可能的功能。 这条线的研究增强了论文的努力，目前集中在15 a-羟化类固醇的结构和功能的海七鳃鳗（Petromyzon marinus）。 我们的目标是确定15 α-羟化类固醇（性腺类固醇）是祖先和普遍的七鳃鳗通过调查他们的作用，在欧洲河七鳃鳗，最衍生七鳃鳗属。 目的是研究七鳃鳗的性腺组织中的类固醇激素在体外，类固醇激素在体内的循环和生产，响应于GnRH管理类固醇水平的变化。 七鳃鳗类类固醇激素的研究对内分泌功能的进化和生物多样性具有重要意义，因为七鳃鳗是最早研究下丘脑-垂体-性腺轴的进化现存脊椎动物。 然而，大多数研究都集中在下丘脑和脑垂体的激素上，并且是在一个单一的物种--七鳃鳗上进行的。 本论文项目将这些研究扩展到几个不同物种的性腺类固醇。 该项目利用了联合王国独特的设施，这些设施中有河七鳃鳗。研究结果将进一步了解各种七鳃鳗物种的保护和控制工作，这些物种在世界不同地区濒临灭绝，受到威胁或被视为入侵物种。