Competitive Student Design of Synthetic Biological Finite State Machines

合成生物有限状态机的竞争性学生设计

• 批准号: 0340562
• 负责人: Thomas Knight
• 金额: $ 40万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0340562&HistoricalAwards=false
• 关键词: Competitive; Student; Design; Synthetic; Biological

Under this project a novel course on the design and fabrication of engineered, synthetic biological systems will be disseminated and co-taught at five universities (MIT, UT Austin, Boston University, Caltech, and Princeton). This effort is analogous to the initial proliferation of VLSI design courses that took place in the late 1970s and early 1980s. In specific, during the project period faculty from each school will spend one week at MIT refining and planning the course, students at each school will spend a summer competing (across schools) to design and build genetically-encoded finite state machines, after which all students and faculty will attend a project-wide jamboree whereat each school's project will be evaluated and design prizes awarded. In addition, during the competition students at each school will be supported by a project-wide Registry of Standard Biological Parts. This multi-school, multi-project design competition is the first multi-site test of such a Registry, and will result in the creation of an open, community-wide resource supporting research and education on synthetic biology. Also resulting from this effort will be (i) an initial set of teachers who are capable of expanding the scope and scale of educational programs that support the engineering of biological systems, (ii) a set of students who have practical experience with the current state and limitations in biological systems design, and (iii) an expanded set of standard biological parts, from which many more schools and researchers will be able to draw upon in support of their own educational initiatives and research.

在该项目下，一个关于工程合成生物系统设计和制造的新课程将在五所大学（麻省理工学院，UT奥斯汀，波士顿大学，加州理工学院和普林斯顿大学）传播和共同教授。这种努力类似于20世纪70年代末和80年代初VLSI设计课程的最初激增。具体来说，在项目期间，每所学校的教师将在麻省理工学院花一周的时间来完善和规划课程，每所学校的学生将花一个夏天的时间来竞争（跨学校）设计和构建遗传编码的有限状态机，之后所有的学生和教师将参加一个项目范围内的大露营，在那里每个学校的项目将被评估并颁发设计奖。此外，在比赛期间，每所学校的学生将得到一个项目范围的标准生物部件登记处的支持。这个多学校，多项目设计竞赛是这样的注册表的第一个多站点测试，并将导致创建一个开放的，社区范围的资源，支持合成生物学的研究和教育。这一努力还将产生（i）一批能够扩大支持生物系统工程的教育计划的范围和规模的教师，（ii）一批对生物系统设计的当前状态和限制具有实践经验的学生，以及（iii）一套扩展的标准生物部件，更多的学校和研究人员将能够利用这些信息来支持他们自己的教育倡议和研究。