US-France Cooperative Research: Electrophysiological Studies of Dopamine in the Dorsal and Ventral Striatum

这个为期三年的奖项支持美国-法国奥尔巴尼医学院的patricia O'Donnell和波尔多第二大学的Francois Gonon在神经科学方面的合作研究。他们的研究目的是在实验条件下，研究内源性释放多巴胺对纹状体神经元的电生理作用，并试图确定哪些神经元对多巴胺敏感。研究人员将利用识别纹状体神经元的电生理记录，并研究内源性释放多巴胺的体内效应。实验条件将试图模拟生理条件。该项目将促进对多巴胺释放的自然过程及其对生理行为过程的影响的理解。美国和法国的研究人员将分享他们在电生理技术（O'Donnell小组）、多巴胺释放的电化学监测（Gonon小组）和解剖功能技术（Gonon小组）方面的互补专业知识。该项目由美国国家科学基金会（NSF）和法国国家科学研究中心（CNRS）联合资助。美国国家科学基金会将支付美国调查员及其团队访问法国的费用。法国研究中心为法国小组访问美国提供支持。

0340577O'DonnellThis three-year award supports U.S.-France cooperative research in neurosciences between Patricio O'Donnell of Albany Medical College and Francois Gonon of the Universite de Bordeaux II. The objective of their research is to study, under experimental conditions, the electrophysiological effects of endogenously released dopamine on striatal neurons and try to identify those neurons that are dopamine sensitive. The investigators will utilize electrophysiological recordings on identified striatal neurons and investigate in vivo the effects of endogenously released dopamine. The experimental conditions will attempt to mimic the physiological conditions. The project will advance understanding of the natural processes involved in dopamine release, its impact on processes involved in physiological behavior. The U.S. and French investigators will share their complementary expertise in electrophysiological techniques (O'Donnell's group), electrochemical monitoring of dopamine release (Gonon's group) and anatomofunctional techniques (Gonon's group).This project is jointly supported by the National Science Foundation (NSF) and the Centre National de la Recherche Scientifique (CNRS). NSF will cover the costs of visits to France by the U.S. investigator and his team. The CNRS provides support to the French team for visits to the United States.