US-France Cooperative Research: Electrophysiological Studies of Dopamine in the Dorsal and Ventral Striatum

美法合作研究：背侧和腹侧纹状体多巴胺的电生理学研究

• 批准号: 0642290
• 负责人: Patricio O'Donnell
• 金额: $ 0.25万
• 依托单位: University of Maryland at Baltimore
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0642290&HistoricalAwards=false
• 关键词: US; France; Cooperative; Research; Electrophysiological

0340577O'DonnellThis three-year award supports U.S.-France cooperative research in neurosciences between Patricio O'Donnell of Albany Medical College and Francois Gonon of the Universite de Bordeaux II. The objective of their research is to study, under experimental conditions, the electrophysiological effects of endogenously released dopamine on striatal neurons and try to identify those neurons that are dopamine sensitive. The investigators will utilize electrophysiological recordings on identified striatal neurons and investigate in vivo the effects of endogenously released dopamine. The experimental conditions will attempt to mimic the physiological conditions. The project will advance understanding of the natural processes involved in dopamine release, its impact on processes involved in physiological behavior. The U.S. and French investigators will share their complementary expertise in electrophysiological techniques (O'Donnell's group), electrochemical monitoring of dopamine release (Gonon's group) and anatomofunctional techniques (Gonon's group).This project is jointly supported by the National Science Foundation (NSF) and the Centre National de la Recherche Scientifique (CNRS). NSF will cover the costs of visits to France by the U.S. investigator and his team. The CNRS provides support to the French team for visits to the United States.

0340577O‘Donnell这个为期三年的奖项支持奥尔巴尼医学院的Patricio O’Donnell和波尔多第二大学的Francois Gonon在神经科学方面的美法合作研究。他们的研究目的是在实验条件下研究内源性释放的多巴胺对纹状体神经元的电生理影响，并试图识别那些对多巴胺敏感的神经元。研究人员将利用已识别的纹状体神经元的电生理记录，并在体内研究内源性释放的多巴胺的影响。实验条件将试图模拟生理条件。该项目将促进对多巴胺释放的自然过程及其对涉及生理行为的过程的影响的理解。美国和法国的研究人员将分享他们在电生理技术(O‘Donnell’s Group)、多巴胺释放的电化学监测(Gonon‘s Group)和解剖功能技术(Gonon’s Group)方面的互补专业知识。该项目由国家科学基金会(NSF)和国家科学研究中心(CNRS)联合支持。NSF将支付美国调查人员和他的团队访问法国的费用。CNRS为法国队访问美国提供支持。