CAREER: Simulating Self-Assembly at Cellular Scales

职业：模拟细胞尺度的自组装

• 批准号: 0346981
• 负责人: Russell Schwartz
• 金额: $ 83.81万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0346981&HistoricalAwards=false
• 关键词: CAREER; Simulating; Self; Assembly; Cellular

ABSTRACTDBI-BDI: 0346981 PI: SchwartzCAREER AwardCarnegie Mellon University has been awarded a grant to develop computational methods for biological modeling and simulation in small to medium size cellular systems. The project will develop methods for simulating self-assembly systems on small to medium scales. Self-assembly systems, collections of molecular subunits that spontaneously assemble into larger structures under appropriate conditions, are crucial to many cellular processes. Accurate models of their behavior on small scales are therefore essential to modeling cell function and reliably predicting cellular responses to various interventions. The project will accomplish this research goal primarily by developing algorithms and theory for small-system discrete-event models to complement prevailing large-system differential equation models. As an integral part of the project methodologies for teaching computional biology will be developed and used in the curriculum at CMU and in teaching computional biology to general biologists. The project is aimed at advancing the field of computional biology through the full integration of innovative and advanced research with the education of a diverse array of students.

摘要DBI-BDI：0346981 PI：SchwartzCAREER AwardCarnegie Mellon University获得了一项资助，用于开发中小型细胞系统的生物建模和模拟计算方法。该项目将开发模拟中小规模自组装系统的方法。自组装系统，即分子亚基在适当条件下自发组装成更大结构的集合，对许多细胞过程至关重要。因此，它们在小尺度上行为的准确模型对于建模细胞功能和可靠地预测细胞对各种干预的反应至关重要。该项目将主要通过开发小系统离散事件模型的算法和理论来实现这一研究目标，以补充流行的大系统微分方程模型。作为该项目的一个组成部分，计算生物学教学方法将被开发和用于CMU的课程和普通生物学家的计算生物学教学。该项目旨在通过将创新和先进研究与多元化学生的教育充分整合，推进计算生物学领域。