CAREER: Development of Chiral Nucleophilic Carbenes for Use in Organic Synthesis

职业：开发用于有机合成的手性亲核卡宾

• 批准号: 0347038
• 负责人: Tomislav Rovis
• 金额: $ 57.7万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0347038&HistoricalAwards=false
• 关键词: CAREER; Development; Chiral; Nucleophilic; Carbenes

Professor Rovis is developing a family of chiral carbenes, derived from amino acids, which place chirality proximal to the carbene carbon. The target chiral triazolylidene carbenes will be explored as nucleophilic catalysts in the Stetter reaction and other nucleophile catalyzed processes. Professor Rovis will also assess the behavior of these carbenes as ligands to modify the reactivity of transition metals in new reaction manifolds, including activation of acidic C-H bonds by rhodium carbene complexes and the direct activation of acidic X-H bonds (X = N, O, etc.) by Lewis basic metal complexes. Professor Rovis will introduce concept mapping to the organic chemistry curriculum, particularly targeting enhanced understanding and performance by non-chemists.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research program of Professor Tomislav Rovis, of the Department of Chemistry at Colorado State University. Professor Rovis is developing a novel class of compounds designed to mediate selective transformations of various types of organic molecules. These studies will lead to the development of new and effective methods for the construction of more complex organic structures, providing powerful tools for the synthesis of compounds displaying desired chemical or biological activity. By introducing concept mapping to the organic chemistry curriculum, Professor Rovis will exploit the power of this technique, in which graphic images are used to illustrate connections between related topics, to enhance understanding and performance by students from non-chemical disciplines. Rather than simply using concept mapping as an assessment tool, Professor Rovis will actively involve students in the instructional process, empowering them to apply concept mapping in their other studies.

Rovis教授正在开发一个手性碳化合物家族，它来源于氨基酸，手性接近碳。目的手性三唑苄基碳烯将在Stetter反应和其他亲核催化过程中作为亲核催化剂进行探索。Rovis教授还将评估这些碳烯作为配体在新反应流形中修饰过渡金属反应活性的行为，包括铑碳烯配合物对酸性C-H键的激活，以及刘易斯碱式金属配合物对酸性X- h键（X = N， O等）的直接激活。Rovis教授将在有机化学课程中引入概念映射，特别是针对非化学家的理解和表现。有了这个职业奖，有机和大分子化学项目支持科罗拉多州立大学化学系Tomislav Rovis教授的教学和研究项目。罗维斯教授正在开发一种新型化合物，用于介导各种有机分子的选择性转化。这些研究将导致开发新的和有效的方法来构建更复杂的有机结构，为合成具有所需化学或生物活性的化合物提供有力的工具。通过将概念映射引入有机化学课程，Rovis教授将利用这一技术的力量，使用图形图像来说明相关主题之间的联系，以提高非化学学科学生的理解和表现。Rovis教授不会简单地将概念图作为一种评估工具，而是会积极地让学生参与到教学过程中，使他们能够将概念图应用到其他研究中。