CAREER: The Development of Hinged Molecular Containers as Fluorescent Sensors of Small Molecules

职业：作为小分子荧光传感器的铰接分子容器的开发

• 批准号: 0348823
• 负责人: Christian Schafmeister
• 金额: $ 61.6万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0348823&HistoricalAwards=false
• 关键词: CAREER; Development; Hinged; Molecular; Containers

Professor Schafmeister is exploring the development of hinged molecular containers as fluorescent sensors of small molecules. Cyclic, chiral building blocks will be joined into spiro-ladder fused-ring oligomers that create complex three-dimensional structures. An amino acid-linked "lid" will provide for ligand-dependent reversible opening and closing of the resulting molecular container. By appending a donor and an acceptor at appropriate positions, this opening and closing will be readily observed via fluorescence measurements. Professor Schafmeister will develop effective tools for the stereographic presentation and visualization of three-dimensional molecular structures, facilitating the communication and learning of these often complex structures. These tools will be disseminated for world-wide use through the Internet.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research activities of Professor Christian E. Schafmeister, of the Department of Chemistry at the University of Pittsburgh. Professor Schafmeister is designing molecules which will specifically recognize and bind selected smaller molecules and in so doing undergo a dramatic and easily measurable change in properties. This basic premise can serve as the basis for the design of molecule-specific sensors and for the construction of selective catalysts for chemical transformations. Professor Schafmeister will facilitate student learning about the three-dimensional complexities of organic chemistry through the development of effective tools for stereographic presentation and visualization, and will make these tools available to others, enhancing the educational experience of students around the world.

Schafmeister教授正在探索铰链分子容器作为小分子荧光传感器的发展。环状手性结构单元将被连接成螺梯稠环低聚物，产生复杂的三维结构。氨基酸连接的“盖”将提供所得分子容器的配体依赖性可逆打开和关闭。通过在适当的位置附加供体和受体，这种打开和关闭将通过荧光测量容易地观察到。Schafmeister教授将开发有效的工具，用于三维分子结构的立体展示和可视化，促进这些通常复杂结构的交流和学习。这些工具将通过互联网传播到世界各地使用。有了这个职业奖，有机和高分子化学计划是支持基督教E教授的教学和研究活动。匹兹堡大学化学系的Schafmeister说。Schafmeister教授正在设计能够特异性识别和结合选定的较小分子的分子，并在这样做的过程中发生显着且易于测量的性质变化。这一基本前提可以作为设计分子特异性传感器和构建化学转化选择性催化剂的基础。Schafmeister教授将通过开发有效的立体展示和可视化工具，促进学生学习有机化学的三维复杂性，并将这些工具提供给他人，增强世界各地学生的教育体验。