CAREER: : Polarizing the Nazarov Cyclization

职业生涯：：纳扎罗夫环化的两极分化

• 批准号: 0349045
• 负责人: Alison Frontier
• 金额: $ 55.6万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0349045&HistoricalAwards=false
• 关键词: CAREER; Polarizing; Nazarov; Cyclization

Professor Frontier will develop Lewis acid-catalyzed Nazarov reactions - electrocyclization of divinyl ketones, affording cyclopentenones via stereospecific conrotatory bond formation. During the project period, Professor Frontier will improve the efficiency of the catalytic Nazarov reaction and achieve asymmetric induction using chiral ligands for the Lewis acid catalyst, identify trends correlating substrate structure with reactivity, define the scope and utility of the reaction, and establish the methodology as a versatile synthetic tool by applying it to the synthesis of representative complex target molecules. Professor Frontier will develop and maintain a Web site designed to serve as a resource and discussion forum for students involved in the laboratory practice of organic chemistry at all levels.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research activities of Professor Alison J. Frontier, of the Department of Chemistry at the University of Rochester. Professor Frontier is developing novel reaction chemistry which allows the facile construction of complex molecular structures from structurally simple precursors. Her studies are providing new tools for selective transformations utlizing only small (catalytic) quantities of reagents and offering promise for general applicability in the synthesis of biologically or chemically active organic molecules. Through the design and maintenance of a Web site serving as a resource and discussion forum for students involved in the laboratory practice of organic chemistry, Professor Frontier is demystifying the successful practice of synthetic organic chemistry and facilitating the widespread sharing of technical expertise and scientific wisdom.

Frontier教授将发展刘易斯酸催化的纳扎罗夫反应 - 二甲基酮的电囊化，通过立体特异性的共骨形成提供环戊烯酮。在项目期间，Frontier教授将提高催化纳扎罗夫反应的效率，并使用手性配体用于路易斯酸催化剂，确定趋势将底物结构与反应性与反应性相关的趋势，定义反应的范围和实用性，并通过将其作为一种多功能合成工具来代表性地构成，并确定方法论是一种多功能合成工具。 Frontier教授将开发和维护一个网站，旨在为参与各级有机化实验室实践的学生提供资源和讨论论坛。在此职业奖的情况下，有机和大分子分子化学计划正在支持罗切斯特大学化学系化学系的教学和研究活动。 Frontier教授正在开发新型的反应化学，该化学允许从结构简单的前体中易于构造复杂的分子结构。她的研究为选择性转化提供了新的工具，仅将小（催化）量的试剂量化，并为合成生物学或化学活性有机分子的合成提供了普遍适用性的希望。通过设计和维护网站，该网站是有机化学实践实践的学生的资源和讨论论坛，Frontier教授正在揭开合成有机化学的成功实践，并促进了技术专业和科学智慧的广泛共享。