MRI: Acquisition of a CryoProbe 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：采购 CryoProbe 500 MHz 核磁共振 (NMR) 波谱仪

• 批准号: 2215973
• 负责人: Alison Frontier
• 金额: $ 60.53万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215973&HistoricalAwards=false
• 关键词: MRI; Acquisition; CryoProbe; 500; MHz

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Rochester is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a liquid nitrogen cooled probe to support the research of Professor Alison Frontier and colleagues Rudi Fasan, Caitlyn R. Kennedy, and Shauna M. Paradine. This instrument facilitates research in the areas of synthesis, peptide chemistry, catalysis, and materials chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in the department. Accessibility of the instrument to science and engineering students promotes their training for future careers.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic organic and inorganic chemistry, polymer science, biochemistry, and biophysics. This instrument enables research focused on the synthesis of complex natural products and other biologically relevant polycycles, catalytic methods for asymmetric synthesis, C-H functionalization of bioactive molecules, and transition metal catalyzed C-C bond formation. It also assists in the preparation of molecular mimics of inorganic and hybrid porous materials and in the dehydrogenation and dehydration of alcohols and amines. Other investigations include the synthesis, characterization, and reactivity of polyoxovanadate-alkoxide clusters and using iron-catalyzed transformations in organic synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目联合支持。罗彻斯特大学正在购买一台500 MHz核磁共振（NMR）光谱仪，配备液氮冷却探头，以支持Alison Frontier教授及其同事Rudi Fasan， Caitlyn R. Kennedy和Shauna M. Paradine的研究。该仪器促进了合成、肽化学、催化和材料化学等领域的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。相对于标准核磁共振探针，氮冷却探针的灵敏度显著提高。该仪器加强了本系各级学生的教育、研究和教学工作。对理工科学生来说，仪器的易用性促进了他们未来职业生涯的训练。授予500 MHz核磁共振光谱仪的目的是加强各级的研究和教育，特别是在合成有机和无机化学、聚合物科学、生物化学和生物物理学等领域。该仪器使研究重点集中在复杂天然产物的合成和其他生物相关的多环，不对称合成的催化方法，生物活性分子的C-H功能化，以及过渡金属催化的C-C键形成。它还有助于无机和杂化多孔材料的分子模拟物的制备以及醇和胺的脱氢和脱水。其他研究包括合成，表征和反应性的多钒氧烷酸簇和使用铁催化转化有机合成。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。