MRI: Acquisition of a CryoProbe 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。罗切斯特大学正在获取一台带有液氮冷却探头的500 MHz核磁共振(核磁共振)光谱仪，以支持Alison Frontier教授及其同事鲁迪·法桑、凯特琳·R·肯尼迪和肖娜·M·帕拉丁的研究。该仪器促进了合成、肽化学、催化和材料化学领域的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。与标准的核磁共振探头相比，氮气冷却探头的灵敏度显著提高。这一工具加强了系内各级学生的教育、研究和教学工作。授予500 MHz核磁共振波谱仪的目的是加强各个层次的研究和教育，特别是在合成有机化学和无机化学、聚合物科学、生物化学和生物物理学等领域。该仪器使研究重点放在复杂的天然产物和其他生物相关多环的合成、不对称合成的催化方法、生物活性分子的C-H官能化以及过渡金属催化的C-C键的形成。它还协助制备无机和杂化多孔材料的分子模拟物，以及醇和胺的脱氢和脱水。其他研究包括多氧钒酸-醇盐簇合物的合成、表征和反应性，以及在有机合成中使用铁催化的转化。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Rochester is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a liquid nitrogen cooled probe to support the research of Professor Alison Frontier and colleagues Rudi Fasan, Caitlyn R. Kennedy, and Shauna M. Paradine. This instrument facilitates research in the areas of synthesis, peptide chemistry, catalysis, and materials chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in the department. Accessibility of the instrument to science and engineering students promotes their training for future careers.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic organic and inorganic chemistry, polymer science, biochemistry, and biophysics. This instrument enables research focused on the synthesis of complex natural products and other biologically relevant polycycles, catalytic methods for asymmetric synthesis, C-H functionalization of bioactive molecules, and transition metal catalyzed C-C bond formation. It also assists in the preparation of molecular mimics of inorganic and hybrid porous materials and in the dehydrogenation and dehydration of alcohols and amines. Other investigations include the synthesis, characterization, and reactivity of polyoxovanadate-alkoxide clusters and using iron-catalyzed transformations in organic synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.