MRI: Acquisition of a CryoProbe 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：采购 CryoProbe 500 MHz 核磁共振 (NMR) 波谱仪

• 批准号: 2215973
• 负责人: Alison Frontier
• 金额: $ 60.53万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215973&HistoricalAwards=false
• 关键词: MRI; Acquisition; CryoProbe; 500; MHz

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Rochester is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a liquid nitrogen cooled probe to support the research of Professor Alison Frontier and colleagues Rudi Fasan, Caitlyn R. Kennedy, and Shauna M. Paradine. This instrument facilitates research in the areas of synthesis, peptide chemistry, catalysis, and materials chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in the department. Accessibility of the instrument to science and engineering students promotes their training for future careers.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic organic and inorganic chemistry, polymer science, biochemistry, and biophysics. This instrument enables research focused on the synthesis of complex natural products and other biologically relevant polycycles, catalytic methods for asymmetric synthesis, C-H functionalization of bioactive molecules, and transition metal catalyzed C-C bond formation. It also assists in the preparation of molecular mimics of inorganic and hybrid porous materials and in the dehydrogenation and dehydration of alcohols and amines. Other investigations include the synthesis, characterization, and reactivity of polyoxovanadate-alkoxide clusters and using iron-catalyzed transformations in organic synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具和化学研究工具计划共同支持。罗切斯特大学（University of Rochester）使用液氮冷却探针获得了500 MHz核磁共振（NMR）光谱仪，以支持Alison Frontier教授和同事Rudi Fasan，Caitlyn R. Kennedy和Shauna M. Paradine的研究。该仪器促进了合成，肽化学，催化和材料化学领域的研究。通常，核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。相对于标准NMR探针，氮冷却探针的灵敏度显着提高。该工具增强了该部门各级学生的教育，研究和教学工作。该工具对科学和工程专业的学生的可及性促进了他们对未来职业的培训。500 MHz NMR光谱仪的奖励旨在增强各级研究和教育，尤其是在合成有机和无机化学，聚合物科学，生物化学和生物物理学等领域。该仪器可以研究重点是复杂的天然产物和其他与生物学相关的多环的合成，非对称合成的催化方法，生物活性分子的C功能化以及过渡金属催化的C-C键形成。 它还有助于制备无机和杂化材料的分子模仿，以及醇和胺的脱氢和脱水。其他研究包括多氧化烷酸 - 烷氧化物簇的合成，表征和反应性，并在有机综合中使用铁催化的转化。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准来通过评估来通过评估来支持的。