Studies on Electrophilic Metal Complexes in Lewis Acid-Catalyzed C-C Bond-Forming Reactions

路易斯酸催化C-C键形成反应中亲电金属配合物的研究

• 批准号: 0847851
• 负责人: Alison Frontier
• 金额: $ 41万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847851&HistoricalAwards=false
• 关键词: Studies; Electrophilic; Metal; Complexes; Lewis

In this collaborative project, the catalytic behavior of cationic octahedral iridium(III) complexes will be investigated in C-C bond-forming reactions. First, thorough investigation of the mechanism of Nazarov cyclization will be conducted, using Ir(III) complexes as a tool to study the complex sequence of steps involved in the reaction. Second, selective methods to conduct new tandem sequences and new methods for enol alkylation using Lewis acidic Ir(III) complexes will be developed. Finally, chiral catalysts for asymmetric Nazarov cyclizations and multi-step sequences based on cationic Ir(III) systems will be synthesized and studied, including new C2 symmetric complexes closely related to the known catalysts possessing adjacent labile binding sites on the catalyst metal center. With this award, the Organic and Macromolecular Chemistry Program is supporting the research collaboration of Professor Alison Frontier and Professor Richard Eisenberg of the Department of Chemistry at the University of Rochester. Research in the catalysis of electrophilic Ir(III) complexes aids in the development of new synthetic methodologies needed for the preparation of commodity and fine chemicals. Increasing molecular complexity through catalysis represents a key means of creating new useful compounds of potential impact beyond the research laboratory.

在这个协作项目中，将在C-C键形成反应中研究阳离子八面体虹膜（III）复合物的催化行为。 首先，将使用IR（III）复合物作为研究反应中涉及的步骤的复杂序列的工具，对纳扎罗夫环化机理进行彻底研究。 其次，将开发使用刘易斯酸性IR（III）配合物进行新的串联序列和新方法进行新的串联序列和新方法。 最后，将合成和研究基于阳离子IR（III）系统的非对称纳扎罗夫循环的手性催化剂和基于阳离子IR（III）系统的多步序列，包括与已知的催化剂密切相关的新C2对称复合物，这些催化剂与具有邻近的催化催化剂，这些催化剂具有邻近的催化剂，这些催化剂在催化剂金属中心上具有相邻的不稳定的衰减。有了这个奖项，有机和大分子化学计划正在支持罗切斯特大学化学系艾莉森·恩德里尔教授和理查德·艾森伯格教授的研究合作。 催化催化的亲电IR（III）复合物的研究有助于开发商品和精细化学物质制备所需的新合成方法。 通过催化提高分子复杂性是创造研究实验室以外潜在影响的新有用化合物的一种关键手段。