Processing of Osseointegrated Dental Implants

骨整合牙种植体的加工

• 批准号: 0349559
• 负责人: Sutapa Bhaduri
• 金额: $ 12.71万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0349559&HistoricalAwards=false
• 关键词: Processing; Osseointegrated; Dental; Implants

This NSF supported project involves a multi-disciplinary team who will develop new manufacturing methods to improve the functionality of dental implants. The goal of this project is to produce dental implants through new powder processing technologies to create functionally graded materials that can be biologically bonded to the human bone. Specifically, the objectives are two-fold: (1) to develop net shape/near net shape Ti implants of dense core with surface porosity that are coated with biocompatible hydroxyapatite (HAp) coating and (2) to characterize the implants in terms of mechanical properties and biocompatibility. The hypothesis is that bone re-growth will be promoted by the pores in the Ti that support the penetration of the HAp coating deeply into the substrate. The dense Ti core will maintain the overall strength. An innovative processing technique will be used to create an inverted porosity in Ti. Thick films of HAp will be deposited on Ti using an electrodeposition technique. The coatings will be characterized by Scanning Electron Microscopy, X-ray diffraction, Confocal Laser Scanning Microscope, and X-ray photoelectron spectroscopy techniques. Mechanical property evaluations such as hardness, fracture strength, and adhesion will be performed to examine the quality of the as-coated implants. In vitro testing in simulated body fluids will be carried out to evaluate its bioactivity. The surface characteristics of the implant in simulated fluid will be studied in situ by an Environmental Scanning Electron Microscope. The participation of local high school students will be one of the outreach activities of this project that will introduce them to the Biomedical Engineering field. The high school students will work with both undergraduates and graduate students on this project, creating an exciting learning environment at all levels.

这个NSF支持的项目涉及一个多学科团队，他们将开发新的制造方法来改善牙科植入物的功能。 该项目的目标是通过新的粉末加工技术生产牙科植入物，以创造可与人体骨骼生物结合的功能梯度材料。 具体而言，目标有两个方面：（1）开发具有表面多孔性的致密芯的净形/近净形钛植入物，其涂覆有生物相容性羟基磷灰石（HAp）涂层，以及（2）表征植入物的机械性能和生物相容性。 假设骨再生长将通过Ti中的孔隙促进，这些孔隙支持HAp涂层深入到基质中。 致密的钛芯将保持整体强度。 将使用创新的加工技术在钛中形成反向孔隙。 HAp的厚膜将使用电沉积技术沉积在Ti上。 涂层将通过扫描电子显微镜、X射线衍射、共聚焦激光扫描显微镜和X射线光电子能谱技术进行表征。 将进行机械性能评价，如硬度、断裂强度和粘附力，以检查涂层植入物的质量。将在模拟体液中进行体外试验，以评价其生物活性。将通过环境扫描电子显微镜原位研究植入物在模拟流体中的表面特征。当地高中生的参与将是该项目的推广活动之一，将向他们介绍生物医学工程领域。 高中生将与本科生和研究生一起参与这个项目，在各个层面创造一个令人兴奋的学习环境。