Flexible Protein Structure Alignment Program and Server

灵活的蛋白质结构比对程序和服务器

• 批准号: 0349600
• 负责人: Adam Godzik
• 金额: $ 60.26万
• 依托单位: Sanford Burnham Prebys Medical Discovery Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0349600&HistoricalAwards=false
• 关键词: Flexible; Protein; Structure; Alignment; Program

The Burnham Institute in California has been awarded a grant to develop modern tools for comparing protein structures by treating them, true to their real character, as flexible entities. Because of the limitations of the currently available protein analysis and comparison tools, a whole class of questions about changes in protein structure cannot be addressed with publicly available software tools. The preliminary results of the flexible protein structure alignment algorithm developed at the Burnham Institute suggest that it will be able to address many of the shortcomings of the rigid body structure comparison programs.

位于加州的伯纳姆研究所获得了一笔赠款，用于开发现代工具，通过将蛋白质结构视为灵活的实体，忠实于它们的真实的特征，来比较蛋白质结构。由于目前可用的蛋白质分析和比较工具的局限性，关于蛋白质结构变化的一类问题不能用公开可用的软件工具来解决。伯纳姆研究所开发的灵活蛋白质结构比对算法的初步结果表明，它将能够解决刚体结构比较程序的许多缺点。