Structure of the essential Commander protein trafficking complex

这个项目旨在提供对指挥官的结构和功能的基本了解，指挥官是一个控制内化受体的出口和循环的大型蛋白质复合体。指挥官在整个进化过程中高度保守，对于维持细胞功能和生存所需的数百种跨膜受体的动态平衡是必不可少的，调节从脂质代谢到细胞黏附的各种过程。尽管对指挥官功能的理解有所进展，但人们对指挥官是如何组装的以及如何与其他必需蛋白质相互作用知之甚少。这个项目将使用多学科的细胞和结构生物学方法来揭示原子水平上的指挥官的架构。

This project aims to provide a fundamental understanding of the structure and function of Commander, a large protein complex that controls export and recycling of internalised receptors. Commander is highly conserved throughout evolution and is essential for maintaining the homeostasis of hundreds of transmembrane receptors required for cell function and survival, regulating processes as diverse as lipid metabolism and cell adhesion. Despite advances in the understanding of Commander function, little is known about how Commander is assembled and interacts with other essential proteins. This project will use multidisciplinary cellular and structural biology approaches to reveal the architecture of Commander at an atomic level.