Structure of the essential Commander protein trafficking complex

必需的指挥官蛋白运输复合体的结构

• 批准号: DP240101315
• 负责人: Prof Brett Collins
• 金额: $ 47.66万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101315
• 关键词: Structure; essential; Commander; protein; trafficking

This project aims to provide a fundamental understanding of the structure and function of Commander, a large protein complex that controls export and recycling of internalised receptors. Commander is highly conserved throughout evolution and is essential for maintaining the homeostasis of hundreds of transmembrane receptors required for cell function and survival, regulating processes as diverse as lipid metabolism and cell adhesion. Despite advances in the understanding of Commander function, little is known about how Commander is assembled and interacts with other essential proteins. This project will use multidisciplinary cellular and structural biology approaches to reveal the architecture of Commander at an atomic level.

该项目旨在提供对指挥官的结构和功能的基本了解，指挥官是一种控制内化受体的出口和回收的大型蛋白质复合物。指挥官在整个进化过程中是高度保守的，对于维持细胞功能和生存所需的数百种跨膜受体的稳态，调节脂质代谢和细胞粘附等多种过程至关重要。尽管对Commander功能的理解取得了进展，但对Commander如何组装并与其他必需蛋白相互作用知之甚少。该项目将使用多学科的细胞和结构生物学方法来揭示指挥官在原子水平上的结构。