CAREER: Vibrational Couplings and Conformational Dynamics of Solvated Systems

职业：溶剂化系统的振动耦合和构象动力学

• 批准号: 0350518
• 负责人: Martin Zanni
• 金额: $ 56.16万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0350518&HistoricalAwards=false
• 关键词: CAREER; Vibrational; Couplings; Conformational; Dynamics

In this CAREER award, supported by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Martin Zanni will conduct research, at the University of Wisconsin, Madison, on the development of the technique of two-dimensional non-linear infrared spectroscopy using femtosecond lasers. The methods developed will be used to study the vibrational dynamics, couplings and folding of DNA and RNA oligomers in solution. In addition, he will train undergraduate, graduate and post-doctoral students in research and develop an active outreach collaboration with an inner-city high school in Chicago. The methods developed by Prof. Zanni may prove to be quite general for studying the dynamics of complex biological molecules. Besides developing these new experimental tools, Prof. Zanni will mentor high-school and undergraduate researchers in his laboratory. He also will begin an outreach program with an inner-city Chicago high school, the Noble Street Charter School. This school has a student body that is 95% underreprensented minority. Prof. Zanni will work with the teachers at the school on a curriculum development plan, incorporating the instructional materials developed by the Material Research Science and Education Center on Nanostructured Materials and Interfaces at the University of Wisconsin.

在化学系实验物理化学项目的支持下，Martin Zanni教授将在麦迪逊的威斯康星州大学进行研究，研究使用飞秒激光的二维非线性红外光谱技术的发展。 开发的方法将用于研究溶液中DNA和RNA寡聚体的振动动力学，耦合和折叠。 此外，他还将培训本科生、研究生和博士后研究生，并与芝加哥市中心的一所高中开展积极的外展合作。Zanni教授开发的方法可能被证明是研究复杂生物分子动力学的通用方法。 除了开发这些新的实验工具外，Zanni教授还将在他的实验室指导高中和本科研究人员。 他还将开始一个外展计划与内城芝加哥高中，贵族街特许学校。 这所学校的学生中95%是少数民族。 Zanni教授将与学校的教师一起制定课程开发计划，并将威斯康星州大学纳米结构材料和界面材料研究科学与教育中心开发的教学材料纳入其中。