Developing surfAce enhaNCEd infrared absorption photonics Quantum Devices for multiple vibrational modes imaging (DANCE-QD)

开发用于多振动模式成像的表面增强红外吸收光子量子器件 (DANCE-QD)

• 批准号: 2893075
• 金额: --
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2893075
• 关键词: Developing; surfAce; enhaNCEd; infrared; absorption

Existing in situ nano biomedical imaging techniques are highly labour and time intensive, often requiring specialist training (e.g. cryo-microscopy), and focus on the analysis of bulk samples due to the scarcity and nanometre scale of intra- or extracellular cell microstructures (e.g. vesicles). The inability of cells and proteins to maintain their structure in dehydrated states also adds further challenges and often results in artefacts. An in situ and rapid technology is therefore required for the in- depth analysis of biological tissues in their native state. Recently, photo-induced force microscopy (PiFM), which provides an external electromagnetic field as a driving force to map 3D chemical and topographical characterisation as a function of phonon energies, has been suggested as a turn-key solution for rapid in situ bio-medical imaging (socially desirable). However, the environmental phonon distribution in liquids creates high background noise due to water molecule vibrations. Vibrational modes can be selectively enhanced using tailored micro-structures, that act as antennas to create local electric field enhancements and near-field coupling to significantly increase near infrared signals. The aim of this studentship is to develop microfabricated antennas as a substrate for in situ aqueous imaging and image reconstruction algorithm development. We will use colloidal semiconductor nanocrystals, quantum materials, two-dimensional materials, metals and photo and electron beam lithography to fabricate micro and nano-photonic structures to enhance IR signals via a PiFM imaging system at Cardiff (unique in UK). Applicants should hold, or expect to receive, a First Class or high Upper Second Class UK Honours degree (or the equivalent) in Electronic Engineering, Physics, and computer science and should have an interest in nano and micro fabrication, clean room processing, and computer vision. A master's level qualification with strong education and research background/experience in electron microscopy, computer vision and image processing and reconstruction would be advantageous.

现有的原位纳米生物医学成像技术是高度劳动和时间密集型的，通常需要专业培训（例如冷冻显微镜），并且由于细胞内或细胞外微结构（例如囊泡）的稀缺性和纳米尺度而专注于批量样品的分析。细胞和蛋白质在脱水状态下无法保持其结构也增加了进一步的挑战，并经常导致伪影。因此，需要一种原位和快速的技术来深入分析处于其天然状态的生物组织。最近，光诱导力显微镜（PiFM），它提供了一个外部的电磁场作为驱动力，以映射三维化学和地形特征作为声子能量的函数，已被建议作为一个交钥匙解决方案，用于快速原位生物医学成像（社会需要）。然而，由于水分子振动，液体中的环境声子分布产生高背景噪声。可以使用定制的微结构来选择性地增强振动模式，所述微结构充当天线以产生局部电场增强和近场耦合以显著增加近红外信号。这个学生的目的是开发微加工天线作为基板的原位水成像和图像重建算法的发展。我们将使用胶体半导体纳米晶体，量子材料，二维材料，金属和光和电子束光刻制造微和纳米光子结构，以增强红外信号通过PiFM成像系统在卡迪夫（在英国唯一）。申请人应持有或期望获得电子工程，物理学和计算机科学的一等或高二等英国荣誉学位（或同等学历），并应对纳米和微制造，洁净室处理和计算机视觉感兴趣。具有电子显微镜，计算机视觉和图像处理和重建方面的良好教育和研究背景/经验的硕士学位将是有利的。