Supramolecular Fixation of Nitrogen Dioxide

二氧化氮的超分子固定

• 批准号: 0350958
• 负责人: Martin Pomerantz
• 金额: --
• 依托单位: University of Texas at Arlington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0350958&HistoricalAwards=false
• 关键词: Supramolecular; Fixation; Nitrogen; Dioxide

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Dmitry Rudkevich of the University of Texas- Arlington proposes to synthesize and investigate the activity of encapsulating chemical cages that trap nitrogen oxide species and can be manipulated through chemical design to catalyze reactions of environmental and biological significance. Professor Rudkevich proposes to use a series of calixarene-NO+ compounds as novel nitrosating agents for organic synthesis. The decreased reactivity of encapsulated NO+ will be used to achieve selective nitrosation. He will also examine the reactivity and rates of encapsulating nitrosating reagents in stereoselective and regioselective reactions with a series of alcohols, thiols, and amides. A systemic approach will be used to gain information on the reactivity and selectivity of new and modified reagents. It is anticipated that these principles will help in the rational design of specific catalyst with future applications to industrial and pharmaceutical syntheses. The Organic and Macromolecular Chemistry Program supports Professors Dmitry Rudkevich of the University of Texas- Arlington who will demonstrate useful applications of NOx which is known to be a significant air pollutant. If the stated goals are achieved, Professor Rudkevich will expand the knowledge currently available in the field of calixarenes and nanotubes. The experimental and theoretical tools that will be used will give students exposure and hands-on experience in modern synthetic chemistry.

在化学学部有机动力学项目的支持下，德克萨斯大学阿灵顿分校的Dmitry Rudkevich教授提议合成并研究一种封装化学笼的活性，这种化学笼可以捕获氮氧化物，并且可以通过化学设计来操纵，以催化具有环境和生物意义的反应。Rudkevich教授建议使用一系列杯芳烃- no +化合物作为有机合成的新型亚硝化剂。包封后的NO+反应活性降低，可用于实现选择性亚硝化。他还将研究包封亚硝化试剂与一系列醇、硫醇和酰胺在立体选择性和区域选择性反应中的反应活性和反应速率。将采用系统的方法来获得有关新试剂和改性试剂的反应性和选择性的信息。预计这些原理将有助于合理设计特定的催化剂，并在未来的工业和药物合成中得到应用。有机和大分子化学项目支持德克萨斯大学阿灵顿分校的Dmitry Rudkevich教授，他将演示氮氧化物的有用应用，氮氧化物是一种已知的重要空气污染物。如果达到既定目标，Rudkevich教授将扩大目前在杯芳烃和纳米管领域的知识。将使用的实验和理论工具将使学生接触和实践现代合成化学的经验。