Intelligent Glucose Microsensor Array with Integrated Electrochemical Actuation System

具有集成电化学驱动系统的智能葡萄糖微传感器阵列

• 批准号: 0400913
• 负责人: Chang-Soo Kim
• 金额: $ 16万
• 依托单位: Missouri University of Science and Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0400913&HistoricalAwards=false
• 关键词: Intelligent; Glucose; Microsensor; Array; Integrated

The electrochemical actuation method based on water electrolysis is used to achieve three novel functionalities; one-point self-calibration (zero-point), extension of linear detection range, and increase in sensitivity. Two kinds of oxygen microenvironments (oxygen-depletion and constant oxygen) can be established by using an integrated electrochemical actuation system around the glucose microsensor. The effect of these two microenvironments on the enzymatic reaction kinetics (oxygen dependency of glucose oxidase reaction) is expected to provide the novel functionalities. The amperometric glucose microsensors are fabricated on a flexible polyimide substrate (Kapton or Upilex ) using integrated circuit technology. The specific objectives are (1) optimization of device structure (geometries of microsensor and microactuator) and actuation signals (magnitude and duration of electrochemical current) to obtain the novel functionalities, (2) development of a smart calibrator based on the stochastic algorithm, and (3) implementation of array to improve reliability.The PI has a joint appointment in the Departments of Electrical & Computer Engineering and Biological Sciences at the University of Missouri-Rolla (UMR). The primary responsibility of the PI is to bridge the gap between the two disciplines through interdisciplinary research activities and education of the students from both departments. The on-campus Minority Engineering Program (MEP) includes offering of freshman/transfer scholarship, hosting seminars on career and educational opportunities, and sponsoring minority engineering student organizations. UMR runs Women in Engineering and Science Program (WIES) and supports a female engineering student organization to increase the number of female graduates entering our nation's technical workforces.

采用基于水电解的电化学驱动方法实现了三个新功能；一点自校准（零点），扩展线性检测范围，提高灵敏度。通过在葡萄糖微传感器周围使用集成电化学驱动系统，可以建立两种氧气微环境（缺氧和恒定氧气）。这两种微环境对酶反应动力学（葡萄糖氧化酶反应的氧依赖性）的影响有望提供新的功能。电流式葡萄糖微传感器采用集成电路技术在柔性聚酰亚胺基板（Kapton 或 Upilex）上制造。 具体目标是（1）优化器件结构（微传感器和微执行器的几何形状）和驱动信号（电化学电流的大小和持续时间）以获得新颖的功能，（2）开发基于随机算法的智能校准器，以及（3）实施阵列以提高可靠性。PI在电气与计算机工程和生物科学系联合任命 密苏里大学罗拉分校（UMR）。 PI的主要职责是通过跨学科研究活动和对两个系学生的教育来弥合两个学科之间的差距。校内少数族裔工程项目 (MEP) 包括提供新生/转学奖学金、举办有关职业和教育机会的研讨会以及赞助少数族裔工程学生组织。 UMR 开展女性工程与科学计划 (WIES)，并支持女性工程学生组织，以增加进入我国技术劳动力队伍的女性毕业生数量。