Intelligent Glucose Microsensor Array with Integrated Electrochemical Actuation System

基于水电解的电化学驱动方法实现了一点自定标(零点)、扩展线性检测范围和提高灵敏度三大新功能。利用集成在葡萄糖微传感器周围的电化学驱动系统，可以建立两种氧气微环境(耗氧型和常氧型)。这两种微环境对酶反应动力学(葡萄糖氧化酶反应的氧依赖性)的影响有望提供新的功能。电流型葡萄糖微传感器是利用集成电路技术在柔性聚酰亚胺(Kapton或Upiex)衬底上制造的。具体目标是(1)优化器件结构(微传感器和微执行器的几何形状)和驱动信号(电化学电流的大小和持续时间)以获得新功能，(2)开发基于随机算法的智能校准器，以及(3)实现阵列以提高可靠性。PI在密苏里大学罗拉分校(UMR)电气与放大；计算机工程和生物科学系联合任命。PI的主要职责是通过跨学科研究活动和对两个系的学生进行教育来弥合两个学科之间的差距。校园少数族裔工程项目(MEP)包括提供新生/转学奖学金，举办关于职业和教育机会的研讨会，以及赞助少数族裔工程学生组织。UMR运营着女性工程和科学项目(WIES)，并支持一个女性工程学生组织，以增加进入我国技术劳动力大军的女性毕业生数量。

The electrochemical actuation method based on water electrolysis is used to achieve three novel functionalities; one-point self-calibration (zero-point), extension of linear detection range, and increase in sensitivity. Two kinds of oxygen microenvironments (oxygen-depletion and constant oxygen) can be established by using an integrated electrochemical actuation system around the glucose microsensor. The effect of these two microenvironments on the enzymatic reaction kinetics (oxygen dependency of glucose oxidase reaction) is expected to provide the novel functionalities. The amperometric glucose microsensors are fabricated on a flexible polyimide substrate (Kapton or Upilex ) using integrated circuit technology. The specific objectives are (1) optimization of device structure (geometries of microsensor and microactuator) and actuation signals (magnitude and duration of electrochemical current) to obtain the novel functionalities, (2) development of a smart calibrator based on the stochastic algorithm, and (3) implementation of array to improve reliability.The PI has a joint appointment in the Departments of Electrical & Computer Engineering and Biological Sciences at the University of Missouri-Rolla (UMR). The primary responsibility of the PI is to bridge the gap between the two disciplines through interdisciplinary research activities and education of the students from both departments. The on-campus Minority Engineering Program (MEP) includes offering of freshman/transfer scholarship, hosting seminars on career and educational opportunities, and sponsoring minority engineering student organizations. UMR runs Women in Engineering and Science Program (WIES) and supports a female engineering student organization to increase the number of female graduates entering our nation's technical workforces.