Pattern Formation of Vascular Smooth Muscle Cells Subject to Mechanical Stretch

机械拉伸下血管平滑肌细胞的模式形成

• 批准号: 0401781
• 负责人: Shu Liu
• 金额: --
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0401781&HistoricalAwards=false
• 关键词: Pattern; Formation; Vascular; Smooth; Muscle

0401781LiuThis proposal is concerned with pattern formation of vascular smooth muscle cells subject to mechanical stretch and is focused on clarifying the mechanism by which cells reorient in response to the stretch and the underlying texture of the substrate, hypothesizing that mechanical stretch influences orientation of collagen bundles, which in turn mediate smooth muscle cell (SMC) migration, determining cell alignment and pattern formation.

该提案涉及血管平滑肌细胞在机械拉伸下的图案形成，并且集中于阐明细胞响应于拉伸而重新定向的机制和基底的潜在纹理，假设机械拉伸影响胶原束的定向，胶原束进而介导平滑肌细胞（SMC）迁移，确定细胞排列和图案形成。