SGER: A Novel Biologically Inspired Painless Blood Collection Method

SGER：一种新颖的生物启发无痛采血方法

• 批准号: 0402857
• 负责人: Melur Ramasubramanian
• 金额: $ 6.96万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0402857&HistoricalAwards=false
• 关键词: SGER; Novel; Biologically; Inspired; Painless

A Novel Biologically Inspired Painless Blood Collection Method M. K. Ramasubramanian, PI, J. F. Tu, Co-PIMechanical and Aerospace EngineeringNC State University, Raleigh, NC [e-mail], [e-mail] The primary objective of this research is to study the mechanics of blood sucking by a mosquito, material and structural characterization of the parts of mosquito anatomy used needed in accomplishing the task, and translate the understanding into engineering specifications for a synthetic mosquito or a swarm of mosquitoes made up of several synthetic mosquitoes operating in parallel, for painless drawing of blood from a live host, including humans. The second objective is to explore novel material systems and manufacturing processes for the mass production of synthetic fascicle and proboscis. Both analytical and experimental approaches will be used to understand the fundamentals of blood sucking by a mosquito, structural behavior of the fascicle, and the manufacture of a synthetic fascicle. The research offers an excellent opportunity to integrate many different fields of science, such as biomaterials, micro-scale mechanics, MEMS, nano-manufacturing, and biology through an inter-disciplinary team. Success of this research will mean that the monitoring of blood constituents on a regular and frequent basis for diseases like diabetes in adults, children, and babies will be painless for millions of people around the world. New courses in bio-mimetic devices design, and nano-manufacturing will be developed for educating future engineers.

M. K. Ramasubramanian， PI， J. F. Tu， co - pim机械与航空航天工程北卡罗来纳州立大学罗利分校[e-mail], [e-mail]本研究的主要目标是研究蚊子吸血的机制，完成这项任务所需的蚊子解剖部分的材料和结构特征。并将这种理解转化为一种合成蚊子或一群由几只合成蚊子并行操作的蚊子的工程规范，用于无痛地从包括人类在内的活体宿主身上抽血。第二个目标是探索大规模生产合成束和鼻的新材料系统和制造工艺。分析和实验方法都将用于了解蚊子吸血的基本原理，神经束的结构行为，以及合成神经束的制造。该研究提供了一个极好的机会，通过跨学科团队整合许多不同的科学领域，如生物材料，微尺度力学，MEMS，纳米制造和生物学。这项研究的成功将意味着，对成人、儿童和婴儿的糖尿病等疾病进行定期和频繁的血液成分监测，对全世界数百万人来说将是无痛的。将开设仿生装置设计和纳米制造的新课程，以培养未来的工程师。