NIRT: Laser-Guided Assembly of Nanosystems

除非纳米尺度的结构可以廉价地组装成一个工作系统，否则纳米技术的前景将无法实现。该提案的目标是开发和测试一种革命性的工具，该工具使用光压力快速组装由尺寸从~ 10 nm到1 mm的结构组成的复杂纳米系统。智力优势：我们计划开发一种工具，使用光压力逐层组装纳米系统，以产生多个独立的光学陷阱，同时在每层中组织数万个纳米级结构。光学陷阱将通过从一个陷阱位置到下一个陷阱位置快速扫描激光束来产生，依赖于介质的粘度来稳定位置直到陷阱被刷新，或者通过产生全息图来产生，其中通过使用空间光调制器控制光束的强度和相位分布来同时产生多个光学陷阱。无论哪种方式，工具都必须在逐层组装期间实时补偿陷阱的散射环境。因此，这一建议的核心有两个要素：1。阱的动态电磁环境的有效模拟，其用于实时预测激光器所需的强度和相位分布;以及2.更广泛的影响：除了开发一种新的纳米级制造工具，利用光组装纳米级物体之外，这项工作还有一个更广泛的影响，这来自于我们选择探索的测试平台的性质，它只能通过光学操作来制造。特别是，我们计划通过我们在“人工细胞骨架”方面的工作，通过使用光镊控制形成细胞结构的分子网络的组装，为理解活细胞中的自组装和运动做出贡献。此外，我们的工作将影响超分子化学在一个根本的方式，通过增加弱的非共价键，形成软凝聚物质系统，如蛋白质，生物膜和DNA的“光学结合”的力量。通过结合光学结合力和超分子力，我们希望能够深入了解超分子聚集体的结构及其相互作用。此外，重要的教育工作计划在每月研讨会，创新的新的跨学科课程，并在研究本科生的广泛参与的形式。

The promise of nanotechnology won't be realized unless nanometer-scale structures can be assembled together inexpensively into a working system. The goal of this proposal is to develop and test a revolutionary tool that uses light-pressure forces to rapidly assemble complex nanosystems comprised of structures ranging in size from ~10nm to 1mm. Intellectual Merit: We plan to develop a tool to assemble a nanosystem layer-by-layer using light pressure forces to produce multiple, independent optical traps for organizing simultaneously tens of thousands of nanometer-scale structures within each layer. The optical traps will be produced either by rapidly scanning a laser beam from one trap location to the next, relying on the viscosity of the medium to stabilize the position until the trap is refreshed, or by generating a hologram, where multiple optical traps are created simultaneously by controlling the intensity and phase profile of the beam using a spatial light modulator. Either way, the tool will have to compensate in real-time for the scattering environment of the trap during the layer-by-layer assembly. Therefore, there are two elements at the core of this proposal: 1. the efficient simulation of the dynamic electromagnetic environment of the trap, which is used to predict in real-time the required intensity and phase profiles for the laser; and 2. the concomitant synthesis through adaptive optics of the trap.Broader Impact: Aside from the development of a new tool for nanoscale manufacturing that assembles nanometer-scale objects using light, there is a broader impact of this work derived from the nature of the testbeds we choose to explore, which can only be fabricated through optical manipulation. In particular, we plan to contribute to the understanding of self-assembly and locomotion in living cells through our work on "artificial cytoskeletons," by using optical tweezers to control the assembly of the molecular networks that form the cell's structure. Moreover, our work will affect supra-molecular chemistry in a fundamental way by augmenting the weak noncovalent bonds that form soft-condensed matter systems such as proteins, biological membranes and DNA with "optical binding" forces. By using optical binding forces in conjunction with supra-molecular forces, we hope to gain insight into the structure of the supra-molecular aggregates and their interactions. In addition, significant educational efforts are planned in the form of monthly seminars, innovative new interdisciplinary courses, and extensive involvement of undergraduate students in the research.