Optical Coherence Tomography, Molecular Guided Imaging, and Surgical Navigation for targeted and controlled Laser Ablation

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This proposal from PI Yang continues work in the development of image-guided techniques for the neurosurgical operating room (OR) and beyond.***Objectives***Our broad goals include:***1) Development of novel imaging methods for tissue detection and delineation***2) Fusion of imaging methods for display and surgical navigation***3) Image-guidance and fusion for therapeutic targeting***4) Imaging methods for monitoring of therapeutic effects***Specific aims are:***1) Continued work on structural and vascular (Speckle Variance and Doppler Optical Coherence Tomography; SV/D-OCT) methods for the detection and delineation of vasculature, with adoption of these methods for functional imaging***2) Continued development of elastography methods for OCT for the delineation of various tissue types, including brain tissue structures and healthy vs. diseased tissues***3) Continued development of molecular fluorescence techniques, with focus on the adoption of quantitative, depth resolved, and 3D methods***4) Fusion of data for OCT and fluorescence with current MVIGS system***5) Optimization of information workflow to prevent cognitive overload***6) Translation of navigation information to robot-mounted ablation lasers for targeted and controlled ablation of structures with OCT control***Technological foci, methods, work to date***Core technologies previously established in by the BBL will continue to be developed, specifically:***1) OCT: An infrared based interferometric method with 10 micron lateral resolution, and depth imaging of up to 3mm. We have continued to develop methods for structural and vascular imaging (SV/D-OCT), as well as OCE, and will continue to translate these to a surgical setting.***2) Molecular guided fluorescence imaging: This method uses specific molecular fluorophores to allow imaging of targets. We have developed a temporally controlled biophotonics operating room allowing for real-time imaging without disruption of workflow, and are working to establish quantitative methods.***3) Machine Vision Image Guided Surgery (MVIGS): We have developed a navigation system that combines structured light with presurgical imaging for tool localization. We aim to continue to look at developing methods for the integration of other imaging modalities with our current navigation system for optimized workflow.***4) Guided Laser Ablation: We have developed methods for OCT-controlled laser ablation using fiber lasers in a size-envelope similar to that of a laptop. We are currently working to characterize these systems, and to use MVIGS with robotics for macroscopic guidance, and OCT and fluorescence for micro-guidance.***Impact***The above research is of particular importance to allow for the translation of these novel technologies into the OR. We aim to bring these technologies into the OR with workflow considerations in mind, and to expand their use beyond the neurosurgical operating room to other areas of surgery and medicine, with opportunity for IP generation and job creation.**