NER: An AFM-based Technique for Nanoscale Flow Mapping

提案编号： CTS-0404167主要制造商：Theodorian Borca-Tasciucinstitution： RENSSELAER POLYPOLYMENNIC INST.NER：一种基于AFM的纳米尺度流图绘制技术该提案是响应纳米尺度科学与工程倡议，NSF 03-043，类别NER而收到的。 了解纳米结构和液-固界面中及其周围的流动的动力学和结构对于未来几代基于流体的生物和化学传感器的发展至关重要。 目前可用的流场表征方法，如激光多普勒测速法（LDV）和粒子图像测速法（PIV）依赖于光学传感，并且在分辨率上受到光波长的限制。 一种新的实验技术的基础上磁力显微镜（MFM）检测铁磁或顺磁性纳米粒子播种流将根据这项补助金。 然后，该技术将被用于在电渗透的微通道流的流场的测量，并在附近的流动中的DNA分子。这些实验将为开展与生物流体和生物传感应用相关的流动研究奠定基础，例如含有DNA分子的流动。这个项目的挑战将由一个在实验测量和理论建模和计算方面都具有专业知识的团队来应对。 这项研究如果成功，将有助于理解纳米级流体流动的关键方面，并为设计更好的微流体和纳米流体系统，用于化学和生物传感以及纳米制造铺平道路。 此外，通过促进对DNA和其他生物分子以及单个细胞附近的流动的研究，这项技术将为理解生物系统中的生理过程开辟新的视野。这将对生物技术产生巨大影响。 拟议的研究活动与全面的教育和推广计划相结合。研究结果将通过一个新的触觉设备接口和在线访问实验和演示纳米级流体流动现象将由本科生开发。

PROPOSAL NO.: CTS-0404167PRINCIPAL INVESTIGATOR: THEODORIAN BORCA-TASCIUCINSTITUTION: RENSSELAER POLYTECHNIC INST.NER: AN AFM-BASED TECHNIQUE FOR NANOSCALE FLOW MAPPING This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 03-043, category NER. Understanding the dynamics and the structure of flows in and around nanostructures and liquid-solid interfaces is critical for the advancement of future generations of fluidic based biological and chemical sensors. Currently available flow field characterization methods such as Laser Doppler Velocimetry (LDV) and Particle Image Velocimetry (PIV) rely on optical sensing and are limited in resolution by the wavelength of light. A novel experimental technique based on Magnetic Force Microscopy (MFM) detection of ferromagnetic or paramagnetic nano-particles seeding the flow will be developed under this grant. The technique will then be utilized for measurements of the flow field in electroosmotic microchannel flows and in the vicinity of a DNA molecule in the flow. These experiments will set the stage to conduct studies of flows relevant to bio-fluidic and bio-sensing applications such as flows containing DNA molecules. The challenges of this project will be met by a team with expertise in both experimental measurements and theoretical modeling and computation. The proposed research, if successful, will lead to an understanding of key aspects of fluid flow at the nanoscale, and will pave the way for designing better microfluidic and nanofluidic systems for chemical and biological sensing and nanomanufacturing. Moreover, by facilitating the study of flows in the vicinity of DNA and other bio-molecules and individual cells this technique will open new horizons for understanding physiological processes in biological systems. This will have a tremendous impact on biotechnology. The proposed research activity is integrated with a comprehensive educational and outreach program. The results will be made available through a novel haptic device interface and on-line accessible experiments and demonstrations of nanoscale fluid flow phenomena to be developed by undergraduate students.