Genetical Genomics of Mutational Variance

突变是所有遗传变异的最终来源。因此，了解突变的性质、频率、效应的分布以及从种群中去除突变负荷的选择力是遗传学的核心问题。在濒危物种和人类种群中，自然选择的力量往往不起作用，突变负荷的积累有可能在这些种群中造成严重的问题。目的是了解在基因表达水平上选择靶向哪些类型的突变以及为什么。

Mutation is the ultimate source of all genetic variation. Understanding the nature of mutation, its frequency, the distribution of effects, and the forces of selection that remove mutational load from populations is therefore a central concern of genetics. The accumulation of mutational load both in endangered species and human populations, where the natural forces of selection tend not to operate, has the potential to create serious problems in these populations. The goal is to understand what types of mutations are targeted by selection at the gene expression level and why.