Genetical Genomics of Mutational Variance

突变变异的遗传基因组学

• 批准号: FT0991525
• 负责人: Prof Mark Blows
• 金额: $ 7.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-02-01 至 2010-09-13
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0991525
• 关键词: Genetical; Genomics; Mutational; Variance

Mutation is the ultimate source of all genetic variation. Understanding the nature of mutation, its frequency, the distribution of effects, and the forces of selection that remove mutational load from populations is therefore a central concern of genetics. The accumulation of mutational load both in endangered species and human populations, where the natural forces of selection tend not to operate, has the potential to create serious problems in these populations. The goal is to understand what types of mutations are targeted by selection at the gene expression level and why.

突变是所有基因变异的最终来源。因此，了解突变的本质、频率、影响的分布，以及从种群中去除突变负荷的选择力量，是遗传学关注的中心问题。在自然选择的力量往往不起作用的濒危物种和人类种群中，突变负荷的积累有可能在这些种群中造成严重的问题。目标是了解在基因表达水平上选择针对哪些类型的突变及其原因。