The Genomic Dimensionality of the Response to Natural Selection

未来农业和医学的许多进步，以及对自然种群和害虫种群适应性进化的理解，都需要发现调节复杂性状表达的基因。微阵列技术处于现代基因组学的前沿，但尽管前景光明，但目前由于大量基因表达谱的分析及其解释相关的重大分析问题，其应用受到限制。分析方法将被开发，这将大大提高转录谱分析的能力，以有效地揭示生物和医学科学中重要表型的关键基因。

Many future advances in agriculture and medicine, as well as an understanding of adaptive evolution in natural and pest populations will require discovering the genes that regulate the expression of complex traits. Microarray technology is at the forefront of modern genomics, but despite its promise, is currently restricted in its utility by significant analytical problems associated with the analysis of the large number of gene expression profiles and their interpretation. Analytical approaches will be developed that will substantially enhance the ability of transcriptional profiling to effectively uncover key genes underlying important phenotypes of interest across the biological and medical sciences.