Why does the genetic nearly-null subspace exist?

为什么存在遗传近零子空间？

• 批准号: DP150101841
• 负责人: Prof Mark Blows
• 金额: $ 45.52万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101841
• 关键词: Why; does; genetic; nearly; null

This project aims to determine why nearly-null genetic subspaces exist by simultaneously measuring the input of new mutational variance in these nearly-null subspaces and the selection that acts on these new mutations to result in the observed low levels of standing genetic variance. The ability of organisms to evolve in response to human disturbance, translocation to new environments, or climate variation is governed by the availability of genetic variation. Recent advances in multivariate genetic analysis have demonstrated that a substantial proportion of a phenotype described by quantitative traits has very little genetic variance associated with it, and will therefore tend to be subjected to evolutionary limits

该项目旨在通过同时测量这些近零子空间中新突变方差的输入以及作用于这些新突变以导致观察到的低水平常备遗传方差的选择来确定为什么存在近零遗传子空间。生物体响应人类干扰、迁移到新环境或气候变化而进化的能力取决于遗传变异的可用性。多变量遗传分析的最新进展表明，由数量性状描述的表型的很大一部分与之相关的遗传变异非常小，因此往往会受到进化的限制