FASEB Conference: Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay, to be held 2004 in Tucson, AZ

FASEB夏季研究会议题为“基因表达的转录后控制：mRNA衰变的机制”将于2004年6月26日至7月1日在亚利桑那州图森举行。mRNA的周转是基因表达的一个关键但经常被忽视的调节器，因为mRNA的稳定性决定了其最终的稳态水平。此外，程序性不稳定性是抑制基因表达的重要机制。此外，越来越多的人认识到，大多数生物体采用mRNA质量监测手段，以确保只有“合适”的转录本离开细胞核并被翻译。靶向mRNA的转换是这一过程的组成部分。最后，新发现的反义调控手段，包括RNA干扰，依赖于选择性mRNA转换来实现其生物学后果。由于所有这些原因，mRNA转换引起了更广泛的生命科学界的极大兴趣。本次会议的目的是探讨在细胞和分子水平上支持mRNA转换的普遍过程的机制。本次会议将集中讨论原核生物和真核生物的mRNA衰变。将涵盖的主题包括原核生物和真核生物的多功能核糖核酸酶，RNA质量控制，mRNA结合蛋白在介导mRNA稳定性中的作用，mRNA衰变和疾病，RNA干扰和mRNA周转的全基因组方法。

The FASEB Summer Research conference entitled "Post-transcriptional control of gene expression: mechanisms of mRNA decay" will be held June 26-July1, 2004, in Tucson, AZ. Turnover of mRNA is a key but frequently unrecognized regulator of gene expression as the stability of an mRNA dictates its ultimate steady-state level. Moreover, programmed instability is an important mechanism of repressing gene expression. In addition, it is increasingly recognized that most organisms employ means of surveillance of mRNA quality to ensure that only "fit" transcripts exit the nucleus and are translated. Targeted mRNA turnover is integral to this process. Finally, newly discovered means of antisense regulation, including RNA interference, rely on selective mRNA turnover for their biological consequences. For all these reasons, mRNA turnover is attracting great interest from the broader life sciences community. The goal of this meeting is to explore the mechanisms that underpin the universal process of mRNA turnover, at both the cellular and molecular levels. This conference will focus on mRNA decay in both prokaryotic and eukaryotic organisms. The topics to be covered include the multifunctional ribonucleases of prokaryotes and eukaryotes, RNA quality control, the role of mRNA binding proteins in mediating mRNA (in)stability, mRNA decay and disease, RNA interference and genome-wide approaches to mRNA turnover.