Development of Rhodium Catalyzed [4+2+2] Cycloaddition Reactions in Organic Synthesis

本研究的重点是开发将无环起始原料转化为八元环的方法。 铑催化的二烯炔[4+2+2]环异构化反应的范围和机制将被检查和研究结果扩展到包括其他底物。此外，铑催化剂系统的性质将被探索。有了这个奖项，有机和高分子化学计划是支持博士斯科特R。德克萨斯大学医学加尔维斯顿分支药理毒理学系的Gilbertson博士说。 Gilbertson博士将专注于开发用于合成八元环的催化方法，这是一类难以通过标准合成方法制备的化合物。 就更广泛的影响而言，该项目具有发展绿色化学和培养研究生的潜力。

The focus of this research is the development of methodology for the transformation of acyclic starting materials into eight member rings. The scope and mechanism of the rhodium catalyzed [4+2+2] cycloisomerization reaction of dienynes will be examined and the findings extended to include other substrates. Further, the nature of the rhodium catalyst system will be explored.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott R. Gilbertson of the Department of Pharmacology & Toxicology at the University of Texas Medical Branch at Galveston. Dr. Gilbertson will focus his work on developing catalytic methodology for the synthesis of eight member rings, a class of compounds difficult to prepare by standard synthetic methods. In terms of broader impacts, the project has potential for developing green chemistry and for the training of graduate students.