Development of Diiron Bridging Acyl Complexes in Organic Synthesis

有机合成中二铁桥酰基配合物的研究进展

• 批准号: 9316821
• 负责人: Scott Gilbertson
• 金额: $ 23.59万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9316821&HistoricalAwards=false
• 关键词: Development; Diiron; Bridging; Acyl; Complexes

9316821 The focus of this research is the use diiron bridging acyl complexes in organic synthesis. There are five specific aspects of these diiron complexes that will be studied. The first is the synthesis and resolution, if necessary, of optically pure chiral complexes. Second is the investigation of reductive cleavage of the metal from the inital products which will allow the metal portion of the molecule to be recycled. Third is the study of the utlity of the formation of thioesters from the oxidation of the diiron acyl complex. Fourth is the examination of these complexes as asymmetric Michael acceptors. Fifth is the investigation of the chemistry of the decarbonylation product. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Scott R. Gilbertson of the Department of Chemistry at Washington University. Professor Gilbertson will focus his work in the area of synthetic methodology by studying the use of diiron organometallic complexes to accomplish a number of novel synthetic transformations. ***

9316821 本研究的重点是利用二铁桥联酰基 有机合成中的配合物具体有五个方面 这些二铁配合物的研究。一是 合成和拆分，如果需要，光学纯的 手性配合物二是侦查还原 从初始产物中分离出金属， 分子中的金属部分将被回收。三是 研究了由硫代磷酸酯形成硫酯的效用， 二铁酰基络合物的氧化。四是考试 这些配合物作为不对称迈克尔受体。五是 脱羰反应的化学研究 产品 有了这个奖项，合成有机计划正在支持 Scott R博士的研究。吉尔伯特森的部门 华盛顿大学的化学系。吉尔伯特森教授会 他的工作集中在综合方法学领域， 使用二铁有机金属络合物来实现 许多新的合成转换。 ***