Developing New Ligand Reactivity Patterns

开发新的配体反应模式

• 批准号: 0414726
• 负责人: Maurice Brookhart
• 金额: $ 47.5万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414726&HistoricalAwards=false
• 关键词: Developing; New; Ligand; Reactivity; Patterns

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program to Professor Joseph Templeton at the University of North Carolina addresses new approaches to catalytic stereoselective synthesis and C-H functionalization. One method of promoting stereoselective intramolecular ligand reactions will be delved by preparing complexes with terminal alkyne ligands adjacent to reactive ligands. Since terminal alkyne C-H sites are particularly susceptible to attack, metallacycles are plausible intermediates in new ligand transformations. A second method is to capitalize on the analogy between four-electron donor alkyne ligands and eta2-nitrile ligands by constructing coordination spheres that will favor pi-coordination of nitriles, which promise to promote intramolecular ligand reactions. Efforts to activate alkanes and arenes with platinum reagents and saturated cycloalkane solvents under mild conditions will be continued with B(C6F5)3 as the activating Lewis acid. The major broader impact is motivating and training undergraduate and graduate students. This project aims toward more efficient and selective catalytic conversion of organic molecules to useful products. Graduate and undergraduate students will receive training in organic synthesis, catalysis development and spectroscopic analysis.

该奖项授予北卡罗来纳州大学的Joseph Templeton教授，该奖项涉及催化立体选择性合成和C-H官能化的新方法。 一种促进立体选择性分子内配体反应的方法将通过制备与反应性配体相邻的末端炔配体的络合物来进行研究。 由于末端炔C-H位点特别容易受到攻击，因此金属杂环是新配体转化中可能的中间体。 第二种方法是利用四电子供体炔配体和η 2-腈配体之间的类似性，通过构建有利于腈的π配位的配位球，这有望促进分子内配体反应。 在温和条件下用铂试剂和饱和环烷烃溶剂活化烷烃和芳烃的努力将继续用B（C6 F5）3作为活化刘易斯酸。 主要的更广泛的影响是激励和培训本科生和研究生。 该项目旨在更有效和选择性地将有机分子催化转化为有用的产品。 研究生和本科生将接受有机合成，催化剂开发和光谱分析方面的培训。