Developing New Ligand Reactivity Patterns

该奖项授予北卡罗来纳大学的Joseph Templeton教授无机化学、生物无机化学和有机金属化学项目，介绍催化立体选择性合成和C-H官能化的新方法。一种促进立体选择性分子内配体反应的方法将通过制备与反应配体相邻的末端炔类配体的络合物来进行。由于末端的烯烃C-H位特别容易受到攻击，因此金属环是新的配体转化中可能的中间体。第二种方法是利用四电子给体炔类配体和乙腈类配体之间的相似之处，通过构建有利于腈类化合物的pi配位的配位球来促进分子内的配体反应。用铂试剂和饱和环烷烃溶剂在温和条件下活化烷烃和芳烃的努力将继续以B(C6F5)3为活化Lewis酸。主要的更广泛的影响是激励和培养本科生和研究生。该项目旨在更高效、更有选择性地将有机分子催化转化为有用的产品。研究生和本科生将接受有机合成、催化开发和光谱分析方面的培训。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program to Professor Joseph Templeton at the University of North Carolina addresses new approaches to catalytic stereoselective synthesis and C-H functionalization. One method of promoting stereoselective intramolecular ligand reactions will be delved by preparing complexes with terminal alkyne ligands adjacent to reactive ligands. Since terminal alkyne C-H sites are particularly susceptible to attack, metallacycles are plausible intermediates in new ligand transformations. A second method is to capitalize on the analogy between four-electron donor alkyne ligands and eta2-nitrile ligands by constructing coordination spheres that will favor pi-coordination of nitriles, which promise to promote intramolecular ligand reactions. Efforts to activate alkanes and arenes with platinum reagents and saturated cycloalkane solvents under mild conditions will be continued with B(C6F5)3 as the activating Lewis acid. The major broader impact is motivating and training undergraduate and graduate students. This project aims toward more efficient and selective catalytic conversion of organic molecules to useful products. Graduate and undergraduate students will receive training in organic synthesis, catalysis development and spectroscopic analysis.