Developing New Ligand Reactivity Patterns

这个无机、生物无机和有机金属化学奖项授予了北卡罗来纳大学的Joseph Templeton教授，他致力于催化立体选择合成和碳氢官能化的新方法。本文将探讨一种促进分子内立体选择性配体反应的方法，即制备末端炔配体与反应性配体相邻的配合物。由于末端炔C-H位点特别容易受到攻击，金属环在新的配体转化中是可能的中间体。第二种方法是利用四电子给体炔配体和乙二腈配体之间的类比，通过构建有利于腈的pi配位的配位球，这有望促进分子内配位反应。以B(C6F5)3为活化路易斯酸，继续在温和条件下用铂试剂和饱和环烷烃溶剂活化烷烃和芳烃。更广泛的影响是激励和培养本科生和研究生。该项目旨在更有效和选择性的催化有机分子转化为有用的产品。研究生和本科生将接受有机合成、催化开发和光谱分析方面的培训。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program to Professor Joseph Templeton at the University of North Carolina addresses new approaches to catalytic stereoselective synthesis and C-H functionalization. One method of promoting stereoselective intramolecular ligand reactions will be delved by preparing complexes with terminal alkyne ligands adjacent to reactive ligands. Since terminal alkyne C-H sites are particularly susceptible to attack, metallacycles are plausible intermediates in new ligand transformations. A second method is to capitalize on the analogy between four-electron donor alkyne ligands and eta2-nitrile ligands by constructing coordination spheres that will favor pi-coordination of nitriles, which promise to promote intramolecular ligand reactions. Efforts to activate alkanes and arenes with platinum reagents and saturated cycloalkane solvents under mild conditions will be continued with B(C6F5)3 as the activating Lewis acid. The major broader impact is motivating and training undergraduate and graduate students. This project aims toward more efficient and selective catalytic conversion of organic molecules to useful products. Graduate and undergraduate students will receive training in organic synthesis, catalysis development and spectroscopic analysis.