Synthesis of Divinylcyclopropanes via Organoiron Methodology and Subsequent Cope rearrangement

这项研究的重点是使用铁的羰基辅助物来介导顺式二乙烯基环丙烷的制备，这些顺式二乙烯基环丙烷将重排得到1，4-环庚烯。此外，(戊二基)铁配合物的稳定性将被用于对顺式-二乙烯基环丙烷的前体进行化学修饰，该方法将被应用于天然产物()-羟基色酮、()-枝花内酯和()-棒状花青素A的合成。唐纳森博士将专注于使用铁介导的合成，然后重排化学来制备七个成员环。生成的中间体将用于合成天然产物。该项目还为本科生和研究生的培训提供了一个极好的场所，并可能在制药行业产生更广泛的影响。

The focus of this research involves the use of an iron carbonyl adjunct to mediate the preparation of cis-divinylcyclopropanes that will rearrange to give 1,4-cycloheptaienes. Further, the stability of (pentenediyl)iron complexes will be utilized to chemically modify precursors to the cis-divinylcyclopropanes and the methodology will be applied to the synthesis of the natural products (+)-hydroxycolorenone, (+)-cladantholide and (+)-clavularin A.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. William A. Donaldson of the Department of Chemistry at the Marquette University. Dr. Donaldson will focus his work on using iron-mediated synthesis followed by rearrangement chemistry to prepare seven membered rings. The resulting intermediates will be used for the synthesis of natural products. The project also provides an excellent venue for the training of undergraduate and graduate students and could have broader impact in the pharmaceutical industry.