Natural Products Synthesis via Organoiron Methodology

该项目将继续开发新的有机金属方法，以立体选择性的方式制备C-C键，并应用这一方法。特别是(2-烯基-3-戊烯-1，5-二基)铁配合物的制备及其转化为乙烯基环丙烷和二乙烯基环丙烷。二乙烯基环丙烷可能发生重排反应生成环庚二烯。这些反应将用于合成β-氨基环丙烷羧酸和前列环素A，一种白细胞介素8与其受体结合的抑制剂。获得这一奖项，有机和高分子化学计划支持马奎特大学化学系的威廉·A·唐纳森教授的研究。唐纳森教授的研究工作围绕着形成环丙烷和环庚二烯的有机金属方法学的发展，这是存在于各种生物相关分子中的结构基元。该方法的成功开发将对制药和农业中的合成产生影响。

This project will continue work to develop new organometallic methodology to prepare C-C bonds in a stereoselective fashion, and applications of this methodology. In particular, the preparation of (2-alkenyl-3-pentene-1,5-diyl)iron complexes and their transformation into vinylcyclopropanes and divinylcyclopropanes will be targeted. The divinylcyclopropanes are likely to undergo rearrangement to cycloheptadienes. These reactions will be applied to the synthesis of beta-aminocyclopropanecarboxylic acids and frondosin A, an inhibitor of the binding of interleukin-8 to its receptor.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor William A. Donaldson of the Department of Chemistry at Marquette University. Professor Donaldson's research efforts revolve around the development of organometallic methodology for the formation of cyclopropanes and cycloheptadienes, structural motifs present in a variety of biologically relevant molecules. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.