Acquisition of a 400 MHz NMR Spectrometer

在主要研究仪器（MRI）计划的支持下，马奎特大学化学系将获得一台400 MHz核磁共振（NMR）光谱仪。该仪器将用于a）通过多核NMR对有机/无机/有机金属起始材料、中间体和反应产物进行常规表征;基于H-H、C-H和C-P偶联以及2D实验进行立体化学分配;使用手性镧系元素位移试剂和/或通过手性Mosher酯分析测定对映体过量; B）基于变温实验确定动态行为和反应动力学; c）获得关于受体/分析物结合平衡的动力学和热力学信息; d）使用T1弛豫测量计算蛋白质-配体距离;以及e）确定蛋白质的相关时间。核磁共振（NMR）光谱是化学家用于阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该设备将加强化学领域内许多前沿领域的研究，从合成/催化，到光谱/光化学，到超分子/纳米结构材料化学，再到化学生物学/药物化学。

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Marquette University will acquire a 400 MHz nuclear magnetic resonance (NMR) Spectrometer. The instrument will be used for a) routine characterization of organic/inorganic/organometallic starting materials, intermediates, and reaction products by multinuclear NMR; stereochemical assignments on the basis of H-H, C-H, and C-P couplings as well as 2D experiments; determination of enantiomeric excess using chiral lanthanide shift reagents and/or by chiral Mosher's esters analysis; b) determination of dynamic behavior and of reaction kinetics on the basis of variable temperature experiments; c) obtaining kinetic and thermodynamic information on receptor/analyte binding equilibria; d) calculation of protein-ligand distances using T1 relaxation measurements; and e) determination of correlation times of proteins.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This equipment will enhance research in a number of cutting-edge fields within chemistry, ranging from synthesis/catalysis, to spectroscopy/photochemistry, to supramolecular/nanostructured materials chemistry, to chemical biology/medicinal chemistry.