SBIR Phase I: Identification of Nematicidal Peptides by Phage Display

SBIR 第一阶段：通过噬菌体展示鉴定杀线虫肽

• 批准号: 0419728
• 负责人: Michelle Hresko
• 金额: $ 10万
• 依托单位: Divergence, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0419728&HistoricalAwards=false
• 关键词: SBIR; Phase; Identification; Nematicidal; Peptides

This Small Business Innovation Research (SBIR) Phase I project proposes to develop transgenic plants that are resistant to plant-parasitic nematode infection and damage. The approach is to use phage display technology to identify small peptides that bind to and interfere with the function of important intestinal proteins. The commercial application of this project will be in the area of nematode control of plants. With the phasing out of methyl bromide, which has caused environmentally negative impacts, the agricultural community faces a major loss of a product that protected plants against soil-borne pathogens including nematodes. The development of transgenic plants that target plant-parasitic nematodes will alleviate one of the major problems of growing crops. Furthermore, the transgenic plants will reduce the amount of chemical nematicides that are being used for plant-parasitic nematode control.

本小型企业创新研究（SBIR）一期项目拟开发抗植物寄生线虫感染和损害的转基因植物。该方法是使用噬菌体展示技术来识别结合并干扰重要肠道蛋白功能的小肽。该项目的商业应用将在植物线虫控制领域。随着对环境造成负面影响的甲基溴的逐步淘汰，农业社区面临着一种保护植物免受包括线虫在内的土壤传播病原体侵害的产品的重大损失。以植物寄生线虫为目标的转基因植物的开发将缓解作物种植的主要问题之一。此外，转基因植物将减少用于控制植物寄生线虫的化学杀线虫剂的用量。