SBIR Phase II: Identification of disease resistance traits to improve the productivity and sustainability of soybean cultivation

SBIR 第二阶段：鉴定抗病性状以提高大豆种植的生产力和可持续性

• 批准号: 2112394
• 负责人: Alex Schultink
• 金额: $ 99.19万
• 依托单位: Fortiphyte, Inc.
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2112394&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Identification; disease

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). The broader impact of this Small Business Innovation Research (SBIR) Phase II project is to improve the productivity, environmental sustainability, and profitability of soybean cultivation. Soybean cultivation is a major driver of rainforest deforestation, motivating improved yields for environmental sustainability. In addition, current commercial soybean varieties are highly susceptible to Asian soybean rust, an aggressive fungal disease that is especially severe in tropical and subtropical climates and can decimate soybean yield. This disease is controlled by chemical fungicides that are expensive, pose risks to the environment and human health, and are becoming less effective as the pathogen develops tolerance to over-used chemicals. This project will enable the development of soybean varieties immune to this disease. This will reduce the need for fungicide use in soybean cultivation, reduce yield loss caused by the pathogen, and improve grower profitability. In addition, this technology can be expanded to other crops.The proposed project will result in the identification of new plant disease resistance traits with activity against the pathogen that causes Asian soybean rust. The typical plant species has hundreds of immune receptor genes which surveil for the presence of invading pathogens. Plant breeders routinely use plant immune receptor genes to develop new disease-resistant crop varieties. However, traditional methods to identify and translate these traits are time-consuming. The proposed work utilizes a rapid gene discovery platform to accelerate identification of new disease resistance traits. This project will identify and test several resistance traits. The identification and cloning of these resistance gene sequences will allow them to be quickly moved into elite soybean varieties, resulting in significant time and labor savings relative to traditional breeding. These traits can be stacked together to confer durable resistance against a broad range of Asian soybean rust strains.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项全部或部分根据2021年美国救援计划法案（公法117-2）资助。 这个小企业创新研究（SBIR）第二阶段项目的更广泛的影响是提高大豆种植的生产力，环境可持续性和盈利能力。大豆种植是雨林砍伐的主要驱动力，促进了环境可持续性的产量提高。 此外，目前的商业大豆品种对亚洲大豆锈病高度敏感，亚洲大豆锈病是一种侵袭性真菌疾病，在热带和亚热带气候中特别严重，可大量减少大豆产量。这种疾病由化学杀真菌剂控制，这些化学杀真菌剂价格昂贵，对环境和人类健康构成风险，并且随着病原体对过度使用的化学品产生耐受性而变得不那么有效。这一项目将有助于开发对这种疾病免疫的大豆品种。这将减少大豆种植中对杀真菌剂的需求，减少病原体造成的产量损失，并提高种植者的盈利能力。此外，这一技术还可以推广到其他作物，拟议的项目将导致鉴定新的植物抗病性状，对引起亚洲大豆锈病的病原体具有活性。典型的植物物种有数百种免疫受体基因，它们可以监视入侵病原体的存在。植物育种者通常使用植物免疫受体基因来开发新的抗病作物品种。然而，识别和翻译这些特征的传统方法是耗时的。这项工作利用快速基因发现平台来加速新抗病性状的鉴定。该项目将鉴定和测试几种抗性性状。这些抗性基因序列的鉴定和克隆将使它们能够快速转移到优良大豆品种中，从而相对于传统育种节省大量时间和劳动力。这些特性可以叠加在一起，赋予对广泛的亚洲大豆锈病菌株的持久抗性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。