SBIR Phase I: DiseaseBlockTM Plants with Immunity to Ralstonia, Xanthomonas and Xylella

本项目为小企业创新研究（SBIR）一期项目，旨在优化基于植物转基因噬菌体蛋白的抗菌技术。具体来说，这个项目将改进创造转基因西红柿所需的方法，这种西红柿表达由噬菌体产生的溶解蛋白，其数量足以杀死植物致病性革兰氏阴性细菌。后续工作将集中于控制天竺葵、柑橘、葡萄和水稻最严重的细菌性病害。该项目的商业应用将在转基因作物领域，以控制一些目前选择有限的非常重要的植物病害。

This Small Business Innovation Research (SBIR) Phase I project proposes to optimize plant transgenic phage protein-based antibacterial technology. Specifically, this project will refine the methodologies needed to create transgenic tomatoes that express holins, lytic proteins produced by bacteriophages, in the amount needed to kill plant-pathogenic gram negative bacteria. The follow-on work will focus on controlling the most serious bacterial diseases of geranium, citrus, grape and rice.The commercial application of this project will be in the area of transgenic crops to control a number of very important plant diseases for which limited options currently exist.