SBIR Phase I: DiseaseBlockTM Plants with Immunity to Ralstonia, Xanthomonas and Xylella

SBIR 第一阶段：对拉尔斯顿氏菌、黄单胞菌和木杆菌具有免疫力的DiseaseBlockTM 植物

• 批准号: 0419936
• 负责人: Chandrika Ramadugu
• 金额: $ 10万
• 依托单位: Integrated Plant Genetics, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0419936&HistoricalAwards=false
• 关键词: SBIR; Phase; DiseaseBlockTM; Plants; Immunity

This Small Business Innovation Research (SBIR) Phase I project proposes to optimize plant transgenic phage protein-based antibacterial technology. Specifically, this project will refine the methodologies needed to create transgenic tomatoes that express holins, lytic proteins produced by bacteriophages, in the amount needed to kill plant-pathogenic gram negative bacteria. The follow-on work will focus on controlling the most serious bacterial diseases of geranium, citrus, grape and rice.The commercial application of this project will be in the area of transgenic crops to control a number of very important plant diseases for which limited options currently exist.

该小型企业创新研究（SBIR）一期项目提出优化基于植物转基因噬菌体蛋白的抗菌技术。具体来说，该项目将完善生产转基因番茄所需的方法，这些番茄表达穴蛋白（噬菌体产生的裂解蛋白），其数量足以杀死植物病原性革兰氏阴性细菌。后续工作将集中于控制天竺葵、柑橘、葡萄和水稻等最严重的细菌性疾病。该项目的商业应用将在转基因作物领域，以控制目前选择有限的一些非常重要的植物病害。