SBIR Phase II: Portable BioDetection Platform for Rapid Identification of Multiple Biological Agents

SBIR II 期：用于快速识别多种生物制剂的便携式生物检测平台

• 批准号: 0422085
• 负责人: Ihab Abdel-Hamid
• 金额: --
• 依托单位: MESOSYSTEMS TECHNOLOGY, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0422085&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Portable; BioDetection

This Small Business Innovation Research Phase II project will develop a portable automated biosensor for detection of proteins, viruses and/or pathogens in liquid and air samples. This technology is based on the integration of highly-specific immunodiagnostics with ultra-sensitive electrochemical sensors in a multiplexed microfluidic format that allows the measurement of up to three proteins, two viruses and two bacteria simultaneously . The biosensor is expected to have low detection limits (that is, of less than 0.5 ng/ml for proteins, 1000 PFU/ml for viruses and 700 CFU/ml for bacteria), with an overall assay time of less than 30 minutes. This system will be tested for detection of potential biological threat agents such as Staphylococcal Enterotoxin B (protein/toxin), Influenza (virus) and Bacillus anthracis (bacteria). The commercial application of this project will be in the areas of homeland security, clinical diagnostics, food quality control and general environmental monitoring.

这个小型企业创新研究第二阶段项目将开发一种便携式自动生物传感器，用于检测液体和空气样品中的蛋白质、病毒和/或病原体。该技术基于高度特异性免疫诊断与超灵敏电化学传感器的集成，采用多路复用微流体格式，允许同时测量多达三种蛋白质，两种病毒和两种细菌。预期生物传感器具有低检测限（即，蛋白质小于0.5 ng/ml，病毒小于1000 PFU/ml，细菌小于700 CFU/ml），总测定时间小于30分钟。该系统将用于检测潜在的生物威胁因子，如葡萄球菌肠毒素B（蛋白质/毒素）、流感（病毒）和炭疽杆菌（细菌）。 该项目的商业应用将在国土安全、临床诊断、食品质量控制和一般环境监测等领域。