SBIR Phase II: Rapid Detection of Bacterial Contaminants Using Micro-Fluidic Biochips

SBIR 第二阶段：使用微流控生物芯片快速检测细菌污染物

• 批准号: 0422150
• 负责人: Laila Razouk
• 金额: --
• 依托单位: Biovitesse, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-11-01 至 2007-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0422150&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Rapid; Detection

This Small Business Innovation Research (SBIR) Phase II project will develop a microfluidic based system for the detection of viable pathogens using dielectric concentration of bacteria as an intermediate step. This system would use a first-stage concentrator, followed by dielectrophoretic concentration, and finally by culturing in media with integrated impedance measurements to detect culture growth. The commercial application of this project will be on the detection of waterborne microorganisms in biopharmaceutical manufacturing operations. The proposed method would electronically detect the viability of microorganisms in water samples in less than 3 hours, unlike the current technology that takes 2-7 days to yield results.

这个小型企业创新研究（SBIR）第二阶段项目将开发一种基于微流体的系统，用于使用细菌的介电浓度作为中间步骤来检测活病原体。该系统将使用第一级浓缩器，随后介电泳浓缩，最后通过在具有集成阻抗测量的培养基中培养来检测培养物生长。该项目的商业应用将是在生物制药生产操作中检测水生微生物。 该方法将在不到3小时的时间内以电子方式检测水样中微生物的活力，而不像目前的技术需要2-7天才能得出结果。