SGER: Experimental Technique to Characterize Droplet Transport in Nanoscale Channels

SGER：表征纳米通道中液滴传输的实验技术

• 批准号: 0424101
• 负责人: Jennifer Lukes
• 金额: --
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2006-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0424101&HistoricalAwards=false
• 关键词: SGER; Experimental; Technique; Characterize; Droplet

Proposal Number: CTS-0424101Principal Investigator: Jennifer LukesAffiliation: University of PennsylvaniaProposal Title: SGER: Experimental technique to characterize droplet transport in nanoscale channelsThe ability to characterize droplet flow through nanoscale fluidic channels will enable tremendous advances in biotechnology and chemical analysis, particularly in the areas of DNA sequencing, drug delivery, chemical separations, and single molecule detection. The goal of this research program is develop a technique capable of such detection. Based on the Coulter counter method widely used to characterize the transport of micron-sized particles in the biological sciences, and inspired by recent successes in characterizing transport of solid particles through nanoscale channels, the proposed experiments are expected to demonstrate the feasibility of detecting the transport of entrained liquid droplets through nanochannels. The work to be performed includes fabricating microchip samples with nanometer-scale channels, filling the channels with an emulsion, locally heating the channel to induce thermocapillary transport of the entrained liquid droplets, and performing time-resolved measurements of the nanochannel electrical conductivity. These measurements will be used to determine the size and velocity of the transported droplets. The novelty of the proposed experiments is that the nanochannels themselves will act as droplet detectors.

提案编号：CTS-0424101首席研究员：詹妮弗·卢克斯隶属于宾夕法尼亚大学提案标题：SGER：表征纳米尺度通道中液滴传输的实验技术表征纳米尺度流体通道中液滴流动的能力将使生物技术和化学分析领域取得巨大进步，特别是在DNA测序、药物输送、化学分离和单分子检测领域。这项研究计划的目标是开发一种能够进行这种检测的技术。基于生物科学中广泛用于表征微米级颗粒传输的库尔特计数器方法，并受到最近在表征纳米级通道中固体颗粒传输的成功的启发，拟议的实验有望证明探测携带液体液滴通过纳米通道传输的可行性。要进行的工作包括制造具有纳米级通道的微芯片样品，在通道中填充乳液，局部加热通道以诱导携带的液滴的热毛细传输，以及对纳米通道的电导率进行时间分辨测量。这些测量将被用来确定传输的液滴的大小和速度。拟议中的实验的新奇之处在于，纳米通道本身将充当液滴探测器。