FIBR - Molecular Evolutionary Ecology of Developmental Signaling Pathways in Complex Environments.

FIBR - 复杂环境中发育信号通路的分子进化生态学。

基本信息

  • 批准号:
    0425759
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-09-01 至 2010-08-31
  • 项目状态:
    已结题

项目摘要

This research project will investigate how plants in natural environments integrate multiple environmental cues in order to flower during favorable seasonal conditions. To this end, it will dissect natural genetic variation in the model plant species Arabidopsis thaliana, combining tools from molecular biology, molecular evolutionary genetics, quantitative genetics, evolutionary ecology, gene network modeling, and biogeography. Major objectives are: 1) to identify natural genetic variants in environmental signal integration; 2) to dissect molecular mechanisms of signal integration; 3) to uncover the evolutionary forces shaping signaling pathways by analyzing DNA sequence variation in candidate genes; 4) to test whether natural variation in these candidate genes contributes to variation in response to multiple environmental cues; 5) to map quantitative trait loci (QTL) contributing to natural variation in flowering responses on a fine genetic scale; 6) to examine the effects of different combinations of natural allelic variants of candidate genes on flowering responses; 7) to model the effects of natural variation in candidate flowering genes on overall flowering pathway function; 8) to test for evidence of local adaptation to climate by examining geographic associations between flowering responses, candidate gene variation, and climate in the site of origin; 9) to measure geographic variation in natural selection by growing lines from different parts of Europe in replicated field experiments across the native European climatic range. Broader impacts: The results of this project will be important for predicting how plants will respond to ongoing climate change. The broad research scope will provide interdisciplinary training to postdoctoral, predoctoral, and undergraduate students as well as K-12 educators. International training collaborations with 7 leading European laboratories will provide unique opportunities for students and postdocs to learn Arabidopsis molecular and population genetics. Thus, future researchers and educators will learn to transcend disciplinary boundaries and integrate molecular and evolutionary approaches to biological problems.
该研究项目将研究自然环境中的植物如何整合多种环境线索,以便在有利的季节条件下开花。 为此,它将剖析模式植物物种拟南芥的自然遗传变异,结合分子生物学,分子进化遗传学,数量遗传学,进化生态学,基因网络建模和植物地理学的工具。主要目标是:1)识别环境信号整合中的自然遗传变异; 2)剖析信号整合的分子机制; 3)通过分析候选基因中的DNA序列变异来揭示塑造信号通路的进化力量; 4)测试这些候选基因中的自然变异是否有助于响应多种环境线索的变异; 5)在精细的遗传尺度上定位影响开花反应自然变异的数量性状基因座(QTL); 6)检测候选基因的自然等位变异体的不同组合对开花反应的影响; 7)模拟候选开花基因的自然变异对整个开花途径功能的影响; 8)通过检查开花反应,候选基因变异,和气候在原产地的网站; 9)测量自然选择的地理变化,通过在整个欧洲本土气候范围内复制的田间实验中,从欧洲不同地区种植品系。更广泛的影响:该项目的结果对于预测植物如何应对持续的气候变化非常重要。广泛的研究范围将提供跨学科的培训,博士后,博士前,和本科生以及K-12教育工作者。 与7个欧洲领先实验室的国际培训合作将为学生和博士后提供学习拟南芥分子和群体遗传学的独特机会。因此,未来的研究人员和教育工作者将学会超越学科界限,整合分子和进化的方法来解决生物学问题。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in Arabidopsis thaliana
大效应开花时间突变揭示了拟南芥适应性景观的条件适应性路径
  • DOI:
    10.1073/pnas.1902731116
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Taylor, Mark A.;Wilczek, Amity M.;Roe, Judith L.;Welch, Stephen M.;Runcie, Daniel E.;Cooper, Martha D.;Schmitt, Johanna
  • 通讯作者:
    Schmitt, Johanna
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Johanna Schmitt其他文献

Population differentiation and genetic variation inform translocation decisions for <em>Liatris scariosa</em> var. <em>novae</em>-<em>angliae</em>, a rare New England grassland perennial
  • DOI:
    10.1016/j.biocon.2005.01.021
  • 发表时间:
    2005-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kelly Gravuer;Eric von Wettberg;Johanna Schmitt
  • 通讯作者:
    Johanna Schmitt
Geographic and seasonal variation in emδ/emsup13/supC values of Csub3/sub plant emarabidopsis/em: Archaeological implications
C3 植物拟南芥的 emδ/emsup13/supC 值的地理和季节变化:考古学意义
  • DOI:
    10.1016/j.jas.2022.105709
  • 发表时间:
    2023-01-01
  • 期刊:
  • 影响因子:
    2.500
  • 作者:
    Catherine G. Cooper;Martha D. Cooper;Michael P. Richards;Johanna Schmitt
  • 通讯作者:
    Johanna Schmitt
Pinoresinol and matairesinol accumulation in a Forsythia × intermedia cell suspension culture
  • DOI:
    10.1023/a:1012909131741
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
    2.400
  • 作者:
    Johanna Schmitt;Maike Petersen
  • 通讯作者:
    Maike Petersen
Maternal Effects of Drought Stress and Inbreeding in Impatiens capensis
干旱胁迫和凤仙花近交对母体的影响
  • DOI:
  • 发表时间:
    2000
  • 期刊:
  • 影响因子:
    0
  • 作者:
    C. Riginos;M. S. Heschel;Johanna Schmitt
  • 通讯作者:
    Johanna Schmitt
Aortic valve stenosis and osteoporosis: insights from a mouse model
  • DOI:
    10.1186/s12872-025-05037-4
  • 发表时间:
    2025-07-31
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Hannah Billig;Johanna Schmitt;Lamia Singer;Christoph Bourauel;Frank A. Schildberg;Werner Masson;Nikola Lübbering;Wenzel Vogel;Sven Perner;Marta Stei;Sven Niepmann;Miriam Silaschi;Farhad Bakhtiary;Georg Nickenig;Sebastian Zimmer
  • 通讯作者:
    Sebastian Zimmer

Johanna Schmitt的其他文献

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{{ truncateString('Johanna Schmitt', 18)}}的其他基金

OPUS: Synthesizing field data in a genomic context to elucidate the evolution of phenotypic plasticity and local adaptation
OPUS:在基因组背景下综合现场数据,以阐明表型可塑性和局部适应的进化
  • 批准号:
    1754102
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Collaborative Research: Integrating Genetically Informed Models of Germination and Flowering to Predict Life History Responses to Changing Climate
合作研究:整合发芽和开花的遗传信息模型来预测生命史对气候变化的反应
  • 批准号:
    1447203
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Collaborative Research: Integrating Genetically Informed Models of Germination and Flowering to Predict Life History Responses to Changing Climate
合作研究:整合发芽和开花的遗传信息模型来预测生命史对气候变化的反应
  • 批准号:
    1020111
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
LiT: Life History Responses to Genetic and Environmental Perturbations in Arabidopsis thaliana
LiT:拟南芥生活史对遗传和环境扰动的反应
  • 批准号:
    0924059
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Dissertation Research - Local Adaptation and Landscape Genetics of Plastic Shade Avoidance Responses in Impatiens capensis.
论文研究 - 凤仙花塑料避荫反应的局部适应和景观遗传学。
  • 批准号:
    0408015
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
ABR: Response to Crowding and Vegetation Shade in Impatiens capensis: Genetic Basis and Fitness Consequences
ABR:凤仙花对拥挤和植被遮荫的反应:遗传基础和适应性后果
  • 批准号:
    0129018
  • 财政年份:
    2002
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Response to Crowding and Vegetation Shade in Impatiens capensis: Genetic Variation and Fitness Consequences
凤仙花对拥挤和植被遮荫的反应:遗传变异和适应性后果
  • 批准号:
    9806858
  • 财政年份:
    1998
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Response to Crowding and Vegetation Shade in Impatiens capensis: Genetic Variation and Fitness Consequences
凤仙花对拥挤和植被遮荫的反应:遗传变异和适应性后果
  • 批准号:
    9708114
  • 财政年份:
    1997
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Collaborative Research: Ecological Genetics of Response to Light in Arabidopsis thaliana (Brassicaceae)
合作研究:拟南芥(十字花科)光反应的生态遗传学
  • 批准号:
    9509239
  • 财政年份:
    1995
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Response to Crowding and Vegetation Shade in Impatiens capensis: Genetic Variation and Fitness Consequences
凤仙花对拥挤和植被遮荫的反应:遗传变异和适应性后果
  • 批准号:
    9306637
  • 财政年份:
    1993
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant

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