Activity-dependent developmental plasticity of gaze-stabilizing reflexes (B12)

凝视稳定反射的活动依赖性发育可塑性 (B12)

• 批准号: 168248231
• 金额: --
• 依托单位: Lehrstuhl für Neurobiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/168248231?language=en
• 关键词: Activity; dependent; developmental; plasticity; gaze

Gaze-stabilization during self-motion requires spatio-temporally adequate sensory-motor transformations and integration with locomotor efference copies. The neuronal circuitries for these computations are formed during embryogenesis but are functionally tuned only post-embryonically. This proposal aims at deciphering mechanistic principles such as the role of intrinsic reference frames and activity-dependent plasticity for brainstem and cerebellar circuit formation and spatio-temporal maturation of vestibular reflexes. The outcome of this proposal will reveal important general rules and requirements for the ontogenetic tuning of sensory-motor integrations necessary for gaze-stabilization.

自我运动过程中的凝视稳定需要时空上足够的感觉-运动转换和运动传出副本的整合。这些计算的神经元电路在胚胎发育过程中形成，但只有在胚胎后才进行功能调整。这项建议旨在破译机制的原则，如内在的参考框架和脑干和小脑回路的形成和前庭反射的时空成熟的活动依赖性可塑性的作用。这项建议的结果将揭示重要的一般规则和要求的个体发育的调节必要的凝视稳定的感觉运动的整合。