Darwinian Chemical Systems

达尔文化学系统

• 批准号: 0434507
• 负责人: Jack Szostak
• 金额: --
• 依托单位: Massachusetts General Hospital
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0434507&HistoricalAwards=false
• 关键词: Darwinian; Chemical; Systems

With this Chemical Bonding Center (CBC) Phase I, Step II award, the Division of Chemistry and the Office of Multidisciplinary Activities of the Mathematical and Physical Sciences Directorate jointly support the research of Jack W. Szostak, of Massachusetts General Hospital, Steven A. Benner, of the University of Florida, and Gerald F. Joyce, of the Scripps Research Institute. This CBC will pursue the long-term goal of synthesizing artificial chemical systems that will exhibit Darwinian evolution. In phase I of the project, a combination of molecular design and laboratory selection will be used to generate RNA-like structures that undergo self-reproduction with heritable mutation. The CBC will utilize the synthetic organic skills of Benner, the expertise in RNA-like systems of Joyce, and the experience of Szostak in the design of in vitro evolution experiments in this highly collaborative endeavor. The synthesis of Darwinian chemical systems will form the basis of a synthetic biology that has the potential of constructing self-replicating systems using the tools of preparative chemistry. This program at the interface of chemistry and biology will provide broad interdisciplinary training for students and is expected to capture the imagination of the public.Chemical Bonding Centers are designed to focus innovative collaborative efforts that address a "big problem" which will lead to a major advance in chemistry or at the interface of chemistry and other sciences and will have the potential to attract broad scientific and public interest.

有了这个化学键合中心（CBC）第一阶段，第二步奖，化学部和数学和物理科学理事会多学科活动办公室共同支持杰克W的研究。马萨诸塞州总医院的Szostak，Steven A.佛罗里达大学的Benner和Gerald F.斯克里普斯研究所的乔伊斯说。 这个CBC将追求的长期目标是合成人工化学系统，将展示达尔文进化论。 在该项目的第一阶段，分子设计和实验室选择的结合将用于产生RNA样结构，这些结构经历具有遗传突变的自我复制。 CBC将利用Benner的合成有机技能，Joyce在RNA样系统方面的专业知识，以及Szostak在这一高度合作的奋进中设计体外进化实验的经验。 达尔文化学系统的合成将形成合成生物学的基础，该合成生物学具有使用制备化学工具构建自我复制系统的潜力。 化学与生物学的交叉点将为学生提供广泛的跨学科培训，并有望抓住公众的想象力。化学结合中心旨在集中创新的合作努力，解决一个“大问题”，这将导致化学或化学与其他科学的交叉点的重大进步，并有可能吸引广泛的科学和公众的兴趣。