SGER: Foundations for Bioproduction

SGER：生物生产的基础

• 批准号: 0434826
• 负责人: Lee Schruben
• 金额: --
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0434826&HistoricalAwards=false
• 关键词: SGER; Foundations; Bioproduction

The promise of bioengineering to improve millions of lives will require efficient production and supply chain logistics systems that can manufacture and deliver millions of high quality, low cost products to patients. The objective of this project is to study how industrial engineering and operations research (IEOR) tools for designing such systems can be applied to biomanufacturing, and to establish a research agenda so that current IEOR tools can be modified, and new tools can be developed, to improve bioproduction systems efficiency. The project goal is to develop a fundamental understanding of biomanufacturing by exploring how differences in production scalability, cross-contamination, regulation, and the therapeutic characteristics of biologics impact production planning, capacity expansion planning and analysis, quality control, supply chain optimization, production economics, and organization structure.Within other high-tech industries, IEOR tools such as simulation, scheduling and production control, capacity planning and production economics, quality control, and supply chain optimization have helped to dramatically increase efficiency. The potential exists to impact the biopharmaceutical industry in the same way. However, this is a very different industry, with its own set of criteria, constraints, and issues that must be understood and quantified. A clear articulation of these issues and potential impact of IEOR technology on the biopharmaceutical industry will help establish a research agenda in this area. This project will include a workshop with both industrial and academic participation as well as form the basis for a new graduate course on logistics and production systems for biomanufacturing. In addition, best practices benchmarking using performance metrics for productivity, speed, flexibility and quality will be initiated.

生物工程改善数百万人生活的承诺将需要高效的生产和供应链物流系统，以制造并向患者提供数百万种高质量、低成本的产品。该项目的目标是研究如何将用于设计此类系统的工业工程和运筹学 (IEOR) 工具应用于生物制造，并制定研究议程，以便修改现有的 IEOR 工具并开发新工具，以提高生物生产系统的效率。该项目的目标是通过探索生物制品的生产可扩展性、交叉污染、监管和治疗特性的差异如何影响生产规划、产能扩张规划和分析、质量控制、供应链优化、生产经济学和组织结构，形成对生物制造的基本了解。在其他高科技行业中，IEOR 工具，如模拟、调度和生产控制、产能规划和生产经济学、质量控制和供应链优化，已有所帮助 显着提高效率。存在以同样方式影响生物制药行业的潜力。 然而，这是一个非常不同的行业，有自己的一套标准、限制以及必须理解和量化的问题。明确阐述这些问题以及 IEOR 技术对生物制药行业的潜在影响将有助于制定该领域的研究议程。该项目将包括一个工业界和学术界共同参与的研讨会，并构成生物制造物流和生产系统新研究生课程的基础。 此外，还将启动使用生产力、速度、灵活性和质量性能指标的最佳实践基准测试。