GOALI: Cartilage Development: Boundary Lubrication

目标：软骨发育：边界润滑

• 批准号: 0439224
• 负责人: Robert Sah
• 金额: --
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0439224&HistoricalAwards=false
• 关键词: GOALI; Cartilage; Development; Boundary; Lubrication

00439224SahThis investigation addresses an important feature of cartilage lubrication, impacting not only our understanding of normal tissue function but also other tissue-engineered approaches that should consider this issue. The research is (1) to determine and compare the molecular basis for lubrication properties of bovine fetal and calf articular cartilage, and (2) to determine if mechanical loading modulates the content of adherent Lubricin/Superficial Zone Protein (Lub/SZP) at the articular surface of fetal and calf cartilage by affecting Lub/SZP synthesis, adhesion, or loss.This project addresses the biological and engineering mechanisms underlying the development of the low-friction surface of normal articular cartilage through a combination of biological, molecular, and biomechanical analyses. The experimental design is based on compelling preliminary data from prior research supported by NSF award BES 9987353. The educational component provides training to undergraduate and graduate students, and, through outreach activities, to students in grades 7-12.Work activities will enhance an existing liaison between academia (University of California San Diego) and industry (BREG, Inc.), drawing on the resources of both partners. The project integrates research, education, and industry in science, math, and engineering by directly engaging undergraduate and graduate students as well as industry engineers in this GOALI research project. The work plan provides a bridge of opportunity for early transfer of knowledge and technologies between academia and industry in the rapidly developing field of tissue engineering.

00439224 Sah这项研究解决了软骨润滑的一个重要特征，不仅影响了我们对正常组织功能的理解，而且影响了其他应该考虑这个问题的组织工程方法。该研究是（1）确定和比较牛胎牛和小牛关节软骨润滑特性的分子基础，以及（2）确定机械载荷是否调节胎牛和小牛关节软骨关节表面粘附润滑素/表浅区蛋白（Lub/SZP）的含量通过影响Lub/SZP合成、粘附、该项目通过生物学、分子学和生物力学分析的结合，阐述了正常关节软骨低摩擦表面发展的生物学和工程学机制。实验设计基于NSF奖项BES 9987353支持的先前研究的引人注目的初步数据。教育部分为本科生和研究生提供培训，并通过推广活动为7- 12年级的学生提供培训。工作活动将加强学术界（加州圣地亚哥大学）和工业界（布雷格公司）之间的现有联系，利用双方的资源。该项目整合了科学，数学和工程领域的研究，教育和工业，直接吸引本科生和研究生以及行业工程师参与该GOALI研究项目。该工作计划为学术界和工业界在快速发展的组织工程领域早期转移知识和技术提供了机会。