SBIR Phase I: HEPbaseTM: Specialized Software for Storage, Retrieval and Linkage of Hepatitis Data

SBIR 第一阶段：HEPbaseTM：肝炎数据存储、检索和链接的专用软件

• 批准号: 0441403
• 负责人: Johanna Craig
• 金额: $ 10万
• 依托单位: GATACA, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0441403&HistoricalAwards=false
• 关键词: SBIR; Phase; HEPbaseTM; Specialized; Software

This Small Business Innovation Research (SBIR) Phase I project will support the development of software which will modernize the way that researchers of the hepatitis epidemic manage and analyze their data. This project will provide a solution for the hepatitis C virologist initially, and will expand to accommodate data from other hepatitis virus strains during Phase II funding and beyond. Scientists need new tools to maximize the value of their collected information. The company will develop software that contains 1) unique applications for integrating multiple sources of disparate data into an automated high-dimensional warehouse, 2) applications that perform repetitious tasks common to HCV genetic research projects, 3) tools that provide novel data annotation capabilities and ultimately new querying methods 4) a specialized alignment tool for automatic alignment of HCV protein sequences and 5) the ability to link HCV protein sequences with host microarray expression data. The result will be software that greatly improves analysis capabilities and reduces data processing time The NSF recognizes that management and analysis of data are critical success factors. If successful the proposed solution will be marketable to hepatitis researchers worldwide in academics, biotechnology, and the pharmaceutical marketplace. The initial focus, hepatitis C (HCV) infection is a serious concern because it is distributed globally, is a chronic manifestation, and is a common co- infection with HIV. HCV infection becomes acute within 20-years post-infection; as HIV infected individuals are living longer because of better medications, HCV co-infection of the HIV patient has become a serious problem. By the year 2005, an estimated 100,000 liver transplants will be needed in the US alone. The importance of tracking the epidemic, both genetically and experimentally, is becoming increasingly important and exceedingly difficult. Understanding the genetic variation in HCV is important because it is implicated in virus-host interactions, severity of infection, sensitivity to infection, and treatment. The proposed solution will dramatically increase the efficiency and productivity of HCV researchers by providing analytical and organizational power specifically designed to address their unique needs.

该小型企业创新研究（SBIR）第一阶段项目将支持软件的开发，该软件将使肝炎流行病研究人员管理和分析数据的方式现代化。该项目最初将为丙型肝炎病毒学家提供一个解决方案，并将在第二阶段资助期间及以后扩展以容纳其他肝炎病毒株的数据。科学家需要新的工具来最大限度地发挥他们收集的信息的价值。该公司将开发包含以下内容的软件：1）用于将多个不同数据源整合到自动化高维数据仓库中的独特应用程序，2）执行HCV遗传研究项目常见的重复任务的应用程序，3）提供新的数据注释能力和最终新的查询方法的工具4）用于HCV蛋白质序列自动比对的专门比对工具和5）将HCV蛋白质序列与宿主微阵列表达数据连接的能力。其结果将是软件，大大提高了分析能力，并减少了数据处理时间的NSF认识到，管理和数据分析是关键的成功因素。如果成功的话，所提出的解决方案将在学术界、生物技术和制药市场上对全世界的肝炎研究人员具有市场价值。最初的焦点，丙型肝炎（HCV）感染是一个严重的问题，因为它分布在全球，是一种慢性表现，是一种常见的艾滋病毒合并感染。HCV感染在感染后20年内变得急性;由于HIV感染者由于更好的药物治疗而活得更长，HIV患者的HCV合并感染已成为严重问题。到2005年，仅在美国就估计需要10万例肝移植。从基因和实验两方面追踪这一流行病的重要性正变得越来越重要，而且极其困难。 了解HCV的遗传变异非常重要，因为它与病毒-宿主相互作用、感染的严重程度、对感染的敏感性和治疗有关。拟议的解决方案将通过提供专门为满足其独特需求而设计的分析和组织能力，大大提高HCV研究人员的效率和生产力。