Mitochondrial Metabolism and Oxidative Efficiency in Drosophila

果蝇线粒体代谢和氧化效率

• 批准号: 0444766
• 负责人: J. William O. Ballard
• 金额: --
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0444766&HistoricalAwards=false
• 关键词: Mitochondrial; Metabolism; Oxidative; Efficiency; Drosophila

Mitochondria are the "power house" of the cell and are responsible for more than 80% of the energy our cells need to function. Their demonstrated role in human disease, and their implied role in neurodegenerative conditions in advanced age makes them particularly relevant given the demographic realities of our society. The low variation within the mitochondrial DNA of most systems limits their power to detect the role of mitochondria in determining host fitness. Drs Ballard and Katewa propose to study mitochondrial metabolism in a model species with high mitochondrial DNA variation. The proposal links population genetics theory with the modeling approach and hypotheses developed by the aging community to study whether the mitochondrial genotype, or mitonuclear interactions influence mitochondrial metabolism in the fly Drosophila simulans. Completion of these studies will make significant contributions to the understanding of the genetic and biochemical mechanisms underlying mitochondrial influences on oxidative metabolism in animals, including humans. The study will result in the mentoring of female undergraduate and graduate students, and a postdoctoral researcher. Results from the studies will be published in peer-reviewed journals, and additional relevant information will be presented on the laboratory homepage.

线粒体是细胞的“能量屋”，负责我们细胞运作所需的80%以上的能量。它们在人类疾病中所表现出的作用，以及它们在老年神经退行性疾病中所隐含的作用，使它们与我们社会的人口现实特别相关。大多数系统的线粒体DNA内的低变异限制了它们检测线粒体在确定宿主适应性中的作用的能力。Ballard和Katewa博士建议在具有高线粒体DNA变异的模式物种中研究线粒体代谢。该提案将群体遗传学理论与老龄化社区开发的建模方法和假设联系起来，以研究线粒体基因型或线粒体相互作用是否影响果蝇中的线粒体代谢。这些研究的完成将为理解线粒体对动物（包括人类）氧化代谢影响的遗传和生化机制做出重大贡献。这项研究将指导女本科生和研究生以及一名博士后研究员。研究结果将发表在同行评审期刊上，其他相关信息将在实验室主页上展示。