CAREER: Protein Structure, Dynamics, and Folding via Ultrafast Multidimensional Infrared Spectroscopy

职业：通过超快多维红外光谱研究蛋白质结构、动力学和折叠

• 批准号: 0450045
• 负责人: Nien-Hui Ge
• 金额: --
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450045&HistoricalAwards=false
• 关键词: CAREER; Protein; Structure; Dynamics; Folding

In this CAREER award, co-funded by the Experimental Physical Chemistry Program of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biosciences, Prof. Nien-Hui Ge of the University of California, Irvine and her post-doctoral and graduate research students will probe the conformational distributions of peptides using multidimensional infrared spectroscopy. The ultimate goal of this research is to uncover the details of how proteins fold and unfold.In addition to her research activities, Prof. Ge will construct an online infrared resource for use in education. The resource will include a database of both ordinary and multidimensional infrared spectra. The resource's most unique feature will be the incorporation of a multidimensional infrared simulator and interactive tutorials designed for use by non-experts. The audience for the online resource includes undergraduate and graduate physical chemistry students, as well as members of the biophysical research community interested in learning how to apply the methods of multidimensional infrared spectroscopy to their own research problems.

在这个由化学系实验物理化学计划和分子和细胞生物科学系分子生物物理计划共同资助的职业奖项中，加州大学欧文分校的葛念辉教授和她的博士后和研究生将利用多维红外光谱来探索多肽的构象分布。这项研究的最终目标是揭示蛋白质如何折叠和展开的细节。除了她的研究活动，葛教授还将构建一个用于教育的在线红外资源。该资源将包括一个普通和多维红外光谱数据库。该资源最独特的功能将是纳入一个多维红外模拟器和为非专家设计的互动教程。在线资源的受众包括本科生和研究生物理化学学生，以及对学习如何将多维红外光谱方法应用于自己的研究问题感兴趣的生物物理研究社区的成员。