Enhancement of Doctoral Research Capacity in Environmental Toxicology at Southern University at Baton Rouge (SUBR)

巴吞鲁日南方大学 (SUBR) 环境毒理学博士研究能力的增强

• 批准号: 0450375
• 负责人: John Owens
• 金额: --
• 依托单位: Southern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-10-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450375&HistoricalAwards=false
• 关键词: Enhancement; Doctoral; Research; Capacity; Environmental

HRD 0450375Enhancement of Doctoral Research Capacity in Environmental Toxicology at Southern University at Baton Rouge (SUBR)Southern University at Baton RougePI- John W. OwensWith NSF support, Southern University at Baton Rouge will strengthen its science, technology, engineering and mathematics educational and research enterprise by expanding interdisciplinary research focused on the effects of environmental pollutants on health at the molecular level. Research topics include: (1) Biochemical Role(s) of Plant and Environmental Estrogens in Hormone-dependent Cancers, (2) Release of Inflammatory Mediators Following Exposure to Particulate Pollution, (3) Interaction of Fluorinated Surfactants with Natural Organic Matter (NOM), (4) Mechanisms of Butadiene-Induced p53-Mediated Apoptotic Signaling, (5) Molecular Basis of Degenerative Diseases Mediated by Oxidative Stress, and (6) Responses of Endothelial Cells to 1,3-Butadiene.The intellectual merit of the research program in environmental toxicology at SUBR is that it makes a significant contribution to the body of knowledge of molecular environmental toxicology in general and to molecular mechanisms associated with the ill effects of 1,3-butadiene in particular. The broader impact the broader impact of the research in environmental toxicology is that it will make a significant contribution to SUBR's mission of becoming nationally competitive as a Doctoral/Research University-Intensive institution. At the same time the program is helping to address the under-representation of Blacks and other minorities in the sciences.

位于巴吞鲁日的南方大学环境毒理学博士研究能力的增强位于巴吞鲁日的南方大学在国家科学基金会的支持下，巴吞鲁日的南方大学将加强其科学、技术、工程和数学教育和研究事业，扩大专注于在分子水平上环境污染物对健康的影响的跨学科研究。研究主题包括：(1)植物和环境雌激素在激素依赖型癌症中的生化作用(S)，(2)暴露于颗粒物污染后炎症介质的释放，(3)含氟表面活性剂与天然有机物(NOM)的相互作用，(4)丁二烯诱导P53介导的凋亡信号的机制，(5)氧化应激介导的退行性疾病的分子基础，以及(6)内皮细胞对1，3-丁二烯的反应。该研究所环境毒理学研究项目的智力价值在于，它对分子环境毒理学的知识体系做出了重大贡献，特别是对与1，3-丁二烯的不良影响相关的分子机制做出了重大贡献。更广泛的影响环境毒理学研究的更广泛的影响是，它将为南加州大学成为博士/研究型大学密集型机构而在全国范围内具有竞争力的使命做出重大贡献。与此同时，该计划正在帮助解决黑人和其他少数民族在科学界代表性不足的问题。