Collaborative Research: Pediatric Vaccine Formulary Optimization and Analysis
合作研究:儿科疫苗配方优化与分析
基本信息
- 批准号:0457176
- 负责人:
- 金额:$ 24.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-08-15 至 2009-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Childhood vaccination has become the single greatest defense against infectious diseases among children in the United States. Moreover, biotechnology breakthroughs are making it possible for vaccine manufacturers to develop vaccine antigens for numerous diseases. One unforeseen consequence of such innovations is that the recommended childhood immunization schedule (as set forth by the Advisory Committee on Immunization Practices) has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. Moreover, health-care decision-makers are being faced with an overwhelming number of choices, with no methodological basis for comparing and evaluating their different vaccine selection options. To address these issues, operations research models and algorithms will formulated to capture the key features of the recommended childhood immunization schedule, as well as the restrictions and requirements as set forth in the national recommended childhood immunization schedule. These decision-making tools will provide health-care administrators with a means to address a variety of important pediatric immunization problems, including the vaccine completion problem, the limited budget problem, and the parent/guardian balking problem. If successful, the models and algorithms developed under this research will provide rigorous formulations for describing a wide variety of pediatric immunization issues. The new models and algorithms obtained will be used to obtain fundamental insights into the public health policies surrounding pediatric immunization and the challenges that must be overcome for health-care decision-makers to be equipped to deal with them. The results of this research will also provide quantitative tools for comparing and evaluating pediatric vaccine formularies necessary to satisfy the recommended childhood immunization schedule. These tools will not only be of value in assessing the current state of pediatric immunization, but also have the potential to be applied to determine the ideal set of new vaccine combinations that should be developed, and to measure the tractability of new immunization policies and requirements for health-care decision-makers. The results of this effort may then lead to higher immunization rates, given the set of vaccine choices available. This research will be conducted in collaboration with personnel within the National Immunization Program at the Centers for Disease Control and Prevention (CDC).
儿童疫苗接种已成为美国儿童对抗传染病的最大单一防御措施。 此外,生物技术的突破使疫苗制造商有可能为许多疾病开发疫苗抗原。 这种创新的一个未预见的后果是,建议的儿童免疫接种时间表(由免疫接种做法咨询委员会提出)已经变得足够拥挤,以至于在这一时间表中增加额外疫苗的前景可能不会受到卫生保健提供者或父母/监护人的欢迎。 此外,卫生保健决策者面临着大量的选择,没有方法学基础来比较和评价他们不同的疫苗选择。 为了解决这些问题,将制定运筹学模型和算法,以捕捉推荐的儿童免疫接种计划的关键特征,以及国家推荐的儿童免疫接种计划中规定的限制和要求。 这些决策工具将为卫生保健管理人员提供一种解决各种重要的儿科免疫问题的方法,包括疫苗完成问题,有限的预算问题和父母/监护人的阻挠问题。如果成功,根据这项研究开发的模型和算法将为描述各种儿科免疫问题提供严格的配方。 获得的新模型和算法将用于获得有关儿科免疫接种的公共卫生政策的基本见解,以及卫生保健决策者必须克服的挑战。 这项研究的结果还将提供定量工具,用于比较和评估满足推荐的儿童免疫接种计划所需的儿科疫苗处方。 这些工具不仅在评估儿科免疫接种的现状方面具有价值,而且有可能应用于确定应开发的理想的新疫苗组合,并衡量新免疫接种政策和卫生保健决策者要求的易处理性。 鉴于现有的一系列疫苗选择,这一努力的结果可能导致更高的免疫接种率。 这项研究将与疾病控制和预防中心(CDC)的国家免疫计划人员合作进行。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sheldon Jacobson其他文献
Comparison of the performance of serum and urine hCG immunoassays in the evaluation of gynecologic patients
- DOI:
10.1016/s0196-0644(85)80924-0 - 发表时间:
1985-11-01 - 期刊:
- 影响因子:
- 作者:
Sonya Naryshkin;Tar C Aw;Marc Filstein;Jane G Murphy;Jerome F Strauss;Fritz L Kiechle;Sheldon Jacobson - 通讯作者:
Sheldon Jacobson
Approach to generalized weakness and peripheral neuromuscular disease.
全身无力和周围神经肌肉疾病的治疗方法。
- DOI:
10.1016/s0733-8627(05)70320-5 - 发表时间:
1997 - 期刊:
- 影响因子:1.2
- 作者:
Frank LoVecchio;Sheldon Jacobson - 通讯作者:
Sheldon Jacobson
Assessing the quality of emergency care: The medical record versus patient outcome
- DOI:
10.1016/s0196-0644(84)80605-8 - 发表时间:
1984-03-01 - 期刊:
- 影响因子:
- 作者:
Jane G Murphy;Sheldon Jacobson - 通讯作者:
Sheldon Jacobson
Satisfaction with practices: Emergency physicians versus internists
- DOI:
10.1016/s0196-0644(87)80172-5 - 发表时间:
1987-03-01 - 期刊:
- 影响因子:
- 作者:
Jane G Murphy;Sheldon Jacobson - 通讯作者:
Sheldon Jacobson
Self-administered nitrous oxide: An adjunct analgesic
- DOI:
10.1016/s0361-1124(79)80149-5 - 发表时间:
1979-03-01 - 期刊:
- 影响因子:
- 作者:
Neal Flomenbaum;E. John Gallagher;Kathleen Eagen;Sheldon Jacobson - 通讯作者:
Sheldon Jacobson
Sheldon Jacobson的其他文献
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{{ truncateString('Sheldon Jacobson', 18)}}的其他基金
Workshop: Setting a Broader Impact Innovation Roadmap; Arlington, Virginia; May 2016
研讨会:制定更广泛影响的创新路线图;
- 批准号:
1629955 - 财政年份:2016
- 资助金额:
$ 24.82万 - 项目类别:
Standard Grant
A Game Theoretic Approach to Pediatric Vaccine Pricing
儿科疫苗定价的博弈论方法
- 批准号:
1161458 - 财政年份:2012
- 资助金额:
$ 24.82万 - 项目类别:
Standard Grant
Exploratory Research On Engineering The Service Sector: Collaborative Research: Research on Designing Vaccine Formularies for Childhood Immunization
工程探索性研究 服务部门:合作研究:儿童免疫疫苗配方设计研究
- 批准号:
0222597 - 财政年份:2003
- 资助金额:
$ 24.82万 - 项目类别:
Standard Grant
Collaborative Research: Aviation Access Control Security Systems
合作研究:航空访问控制安全系统
- 批准号:
0114499 - 财政年份:2001
- 资助金额:
$ 24.82万 - 项目类别:
Standard Grant
Local Search Strategies Using Generalized Hill Climbing Algorithms
使用广义爬山算法的本地搜索策略
- 批准号:
9907980 - 财政年份:2000
- 资助金额:
$ 24.82万 - 项目类别:
Continuing Grant
Engineering Research Equipment: Workstations for Computational Studies in Large-Scale Simulation and Mathematical Programming Research
工程研究设备:大规模仿真和数学规划研究中的计算研究工作站
- 批准号:
9423929 - 财政年份:1995
- 资助金额:
$ 24.82万 - 项目类别:
Standard Grant
Research Initiation: Building and Analyzing Discrete Event Simulation Models of Complex Systems -- A Computational Complexity Approach
研究启动:复杂系统离散事件仿真模型的构建和分析——计算复杂性方法
- 批准号:
9409266 - 财政年份:1994
- 资助金额:
$ 24.82万 - 项目类别:
Standard Grant
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